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	Full-field OCT for developmental biology - art. no. 65341U
	Wang, Rui ; Xue, Ping ; Bai, Wenjia ; Chen, Dieyan
	2010-05-06 ; 2010-05-06
会议名称	Fifth International Conference on Photonics and Imaging in Biology and Medicine, Pts 1 and 2 ; 5th International Conference on Photonics and Imaging in Biology and Medicine ; Wuhan, PEOPLES R CHINA ; Web of Science ; INSPEC
关键词	developmental biology pre-implementation genetic diagnosis full field OCT EMBRYOS Biophysics Engineering, Biomedical Optics Radiology, Nuclear Medicine & Medical Imaging
中文摘要	In this paper, we developed a full-field OCT system using thermal light as the low-coherence light source. A well-known Linnik interferometer configuration was used. Broad spectral width of the thermal light 450-650nm was used to achieve high axial resolution of 1.1 mu M in biological sample for OCT imaging. Two water immersion objectives of 0.5N.A were used to balance the dispersion and a transverse resolution of 0.7 mu m was obtained. With a fast machine-coding algorithm, system sensitivity of more than 80dB and imaging rate as high as 18frame/s with 500x500 pixels per frame could be achieved. Mouse embryos were imaged in vivo with full-field OCT at different depth for the developmental study. Useful information for pre-implementation genetic diagnosis (PGD) was obtained by image analysis and segmentation. As far as known, for the fist time, 3D images of mammalian embryos were obtained with full-field OCT without the need of dye labeling.
会议录出版者	SPIE-INT SOC OPTICAL ENGINEERING ; BELLINGHAM ; 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/6891]
专题	清华大学
推荐引用方式 GB/T 7714	Wang, Rui,Xue, Ping,Bai, Wenjia,et al. Full-field OCT for developmental biology - art. no. 65341U[C]. 见:Fifth International Conference on Photonics and Imaging in Biology and Medicine, Pts 1 and 2, 5th International Conference on Photonics and Imaging in Biology and Medicine, Wuhan, PEOPLES R CHINA, Web of Science, INSPEC.

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