Uptake of transferrin-conjugated quantum dots in single living cells

CORC > 清华大学

	Uptake of transferrin-conjugated quantum dots in single living cells
	Chen DN(陈丹妮) ; Xu GX(许改霞) ; Bahi Ahmed Ali ; Ken-Tye Yong ; Zhou CH(周翠红) ; Wang XM(王晓梅) ; Qu JL(屈军乐) ; Paras N.Prasad ; Niu HB(牛憨笨)
刊名	http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=GXKB201010007&dbname=CJFQ2010
	2012-04-26 ; 2012-04-26
中文摘要	We study the uptake and distribution of transferrin (Tf)-conjugated CdSe/CdS/ZnS quantum dots (QDs) in single living HeLa cells with both fluorescence confocal microscopy and three-dimensional (3D) reconstruction technique. By increasing the co-incubation time or the dosage of QDs-Tf, we find that the uptake of QDs-Tf bioconjugates in the cells increases correspondingly, but with different uptake rates. Additionally, the distribution of QDs-Tf, in single live HeLa cells is time dependent. To our knowledge, this is the first study on quantitatively analyzing the uptake and distribution of bioconjugated QDs in single living cells. Such QDs nanoplatform can be further modified for developing biomedical evaluation tool in cancer diagnosis and targeted drug delivery.
语种	中文
其他责任者	College of Optoelectronic Science and Engineering ; Huazhong University of Science and Technology ; Institute of Optoelectronics ; Key Lab of Optoelectronics Devices and Systems of Ministry of Education/Guangdong Province ; Shenzhen Key Lab of Biomedicine Engineering ; Shenzhen University ; College of Medicine ; Mubarak City for Scientific Research and Technology Applications ; School of Electrical and Electronic Engineering ; Nanyang Technological University ; Institute for Laser ; Photonics and Biophotonics ; State University of New York at Buffalo
内容类型	期刊论文
源URL	[http://ircloud.calis.edu.cn/hdl/244041/53]
专题	清华大学
推荐引用方式 GB/T 7714	Chen DN,Xu GX,Bahi Ahmed Ali,et al. Uptake of transferrin-conjugated quantum dots in single living cells[J]. http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=GXKB201010007&dbname=CJFQ2010,2012, 2012.
APA	陈丹妮.,许改霞.,Bahi Ahmed Ali.,Ken-Tye Yong.,周翠红.,...&牛憨笨.(2012).Uptake of transferrin-conjugated quantum dots in single living cells.http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=GXKB201010007&dbname=CJFQ2010.
MLA	陈丹妮,et al."Uptake of transferrin-conjugated quantum dots in single living cells".http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=GXKB201010007&dbname=CJFQ2010 (2012).