氟调醇的环境污染与毒理学研究

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	氟调醇的环境污染与毒理学研究
	李忠民; 郭良宏
刊名	化学进展
	2016
卷号	28 期号:7 页码:993-1005
关键词	氟调醇多氟和全氟化合物环境污染生物转化毒性效应
其他题名	Environmental Occurrence and Toxicology of Fluorotelomer Alcohols
中文摘要	多氟和全氟烷基化合物(PFASs)由于其独特的稳定性、疏水性和疏油性被广泛用于生产和生活中。PFASs的生产方式有两种:电化学氟化法(ECF)和调聚反应。由于持久性、毒性和生物富集性,ECF生产过程中产生的全氟辛烷磺酸(PFOS)及其盐和全氟辛基磺酰胺(POSF)于2009年被正式列入《斯德哥尔摩公约》的POPs名单,发达国家也开始逐渐停止用ECF方法生产PFASs。因此,调聚反应产生的PFASs前驱体氟调醇(FTOHs)的产量不断增加。研究表明,FTOHs经生物或非生物转化能够生成全氟烷基羧酸(PFCAs),可能是PFCAs污染的间接来源。此外,FTOHs的一些中间代谢产物能够与多种生物分子共价结合,引起严重的毒性效应,而代谢终产物又能引起肝毒性和肾毒性等。近年来,FTOHs的环境问题已成为环境科学、毒理学和流行病学领域的研究热点。本文综述了FTOHs的生产状况、环境污染水平和相关代谢产物的毒性。最后讨论了目前存在的问题,并对未来的研究进行了展望。
英文摘要	Poly- and perfluoroalkyl substances (PFASs) are a family of anthropogenic chemicals widely used in the commercial and industrial applications due to their unique properties of stability, hydrophobicity and lipophobicity. Traditionally, PFASs are produced via two major manufacturing processes: electrochemical fluorination (ECF) and telomerization. Due to their persistence, toxicity and bioaccumulation,ECF-associated chemicals perfluorooctane sulfonic acid (PFOS),its salts and perfluorooctane sulfonyl fluoride (POSF) are placed into the Annex B of the Stockholm Convention (SC) on Persistent Organic Pollutants (POPs) in 2009. The ECF production has also been phased out gradually in the developed countries. However, the production of fluorotelomer alcohols (FTOHs) by telomerization has increased significantly. Recent studies have demonstrated that the biotransformation and abiotic transformation of FTOHs yielded perfluocarboxylic acids (PFCAs),which may be router for the ubiquitous distribution of PFCAs. Besides, some of the FTOHs intermediate metabolites have been demonstrated to be able to covalently bind with various biomolecules and thereby cause serious toxicity,while the final metabolites are showed to cause hepatotoxicity and renal toxicity. Recently, the environmental problems related to FTOHs have become the hotspots in environmental science, toxicology and epidemiology. This paper reviews the research progress on the production status,environmental occurrence,and the toxicities of FTOHs and the related metabolites. Finally, the currently existing problems and trends are discussed.
收录类别	CSCD
CSCD记录号	CSCD:5846390
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/36597]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	李忠民,郭良宏. 氟调醇的环境污染与毒理学研究[J]. 化学进展,2016,28(7):993-1005.
APA	李忠民,&郭良宏.(2016).氟调醇的环境污染与毒理学研究.化学进展,28(7),993-1005.
MLA	李忠民,et al."氟调醇的环境污染与毒理学研究".化学进展 28.7(2016):993-1005.