Ent-Abietanoids Isolated from Isodon serra | |
Wan, Jun1,2; Jiang, Hua-Yi1,2; Tang, Jian-Wei1,2; Li, Xing-Ren1,2; Du, Xue1; Li, Yan1![]() ![]() ![]() | |
刊名 | MOLECULES
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2017-02-01 | |
卷号 | 22期号:2页码:309 |
关键词 | Isodon serra ent-abietane diterpenoids anti-inflammation cytotoxicity |
英文摘要 | Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3,14)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 M) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). |
类目[WOS] | Chemistry, Organic |
研究领域[WOS] | Chemistry |
关键词[WOS] | RABDOSIA-SERRA ; CELL-LINES ; DITERPENOIDS ; ORIDONIN ; INHIBITION ; HARA |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000395552400123 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/50994] ![]() |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing 100039, Peoples R China |
推荐引用方式 GB/T 7714 | Wan, Jun,Jiang, Hua-Yi,Tang, Jian-Wei,et al. Ent-Abietanoids Isolated from Isodon serra[J]. MOLECULES,2017,22(2):309. |
APA | Wan, Jun.,Jiang, Hua-Yi.,Tang, Jian-Wei.,Li, Xing-Ren.,Du, Xue.,...&Pu, Jian-Xin.(2017).Ent-Abietanoids Isolated from Isodon serra.MOLECULES,22(2),309. |
MLA | Wan, Jun,et al."Ent-Abietanoids Isolated from Isodon serra".MOLECULES 22.2(2017):309. |
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