A Reactive O-1(2) - Responsive Combined Treatment System of Photodynamic and Chemotherapy for Cancer

	A Reactive O-1(2) - Responsive Combined Treatment System of Photodynamic and Chemotherapy for Cancer
	Wang, Xiaojun 1,2; Meng, Guoqing 3; Zhang, Song 4; Liu, Xinli 4
刊名	SCIENTIFIC REPORTS
	2016-07-22
卷号	6
英文摘要	The development of reactive oxygen species (ROS)-responsive drug delivery and drug release has gradually attracted much attention in recent years as a promising therapeutic strategy. Singlet oxygen (O-1(2)) as the major ROS species is widely used in photodynamic therapy (PDT) of cancer. In the present study, we introduce a combined treatment using ROS-sensitive thioketal (TK) linkage as a linker between upconversion nanoparticles (UNs)-based PDT and doxorubicin (DOX)-based chemotherapy. UNs can not only play a role in PDT, but can also be used as a nanocarrier for drug delivery of DOX. Moreover, the products of O-1(2) during PDT are able to cleave TK linker inducing the release of DOX which can further achieve the goal of chemotherapy. By using this O-1(2)-responsive nanocarrier delivery system, DOX can easily reach the tumor site and be accumulated in the nuclei to effectively kill the cancer cells, and therefore decreasing the side effects of chemotherapy on the body. Thus, PDT also has the function of controlling drug release in this combination treatment strategy. Compared with monotherapy, the combination of PDT with chemotherapy also possesses excellent drug loading capability and anticancer efficiency.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	UP-CONVERSION NANOPARTICLES ; NEAR-INFRARED LIGHT ; TARGETED DRUG-DELIVERY ; MESOPOROUS SILICA NANOPARTICLES ; SINGLET OXYGEN ; THERAPY ; TUMOR ; DOXORUBICIN ; CELLS ; THERANOSTICS
收录类别	SCI
语种	英语
WOS记录号	WOS:000380031200001
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/2910]
专题	天津工业生物技术研究所_总体研究部_期刊论文
作者单位	1.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Heze Univ, Dept Life Sci, Heze 274015, Peoples R China 4.Qilu Univ Technol, Shandong Prov Key Lab Microbial Engn, Jinan 250100, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiaojun,Meng, Guoqing,Zhang, Song,et al. A Reactive O-1(2) - Responsive Combined Treatment System of Photodynamic and Chemotherapy for Cancer[J]. SCIENTIFIC REPORTS,2016,6.
APA	Wang, Xiaojun,Meng, Guoqing,Zhang, Song,&Liu, Xinli.(2016).A Reactive O-1(2) - Responsive Combined Treatment System of Photodynamic and Chemotherapy for Cancer.SCIENTIFIC REPORTS,6.
MLA	Wang, Xiaojun,et al."A Reactive O-1(2) - Responsive Combined Treatment System of Photodynamic and Chemotherapy for Cancer".SCIENTIFIC REPORTS 6(2016).