Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer

CORC > 天津工业生物技术研究所 > 结构生物信息学和整合系统生物学实验室宋江宁 > 期刊论文

	Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer
	Yang, Yuan 1,2; Wang, Wenjing 1,3; Zhang, Liangcai 4; Zhang, Shihua 5; Liu, Guiyou 6; Yu, Yingcui 7; Liao, Mingzhi 1
刊名	ONCOTARGET
	2016-05-03
卷号	7 期号:18 页码:25528-25534
关键词	prostate cancer rs6983267 meta-analysis risk association
英文摘要	Many studies have investigated the association between single nucleotide polymorphism (SNP) rs6983267 and the risk of prostate cancer. However, results of these studies are inconsistent. Therefore, we summarised available data and performed a meta-analysis to determine this association. Relevant articles were identified by searching the PubMed, Web of Science and Embase database. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random effects model. We used dominant model (GG + TG vs TT), recessive model (GG vs TG + TT) and additive model (GG + TT vs TG) to determine the association between the rs6983267 polymorphism and risk of prostate cancer. Summary, 9 studies involving 8726 participants were included in this meta-analysis. Overall, though no association was observed between the rs6983267 polymorphism and risk of prostate cancer, subgroup analysis according to ethnicity showed a significant association between the rs6983267 polymorphism and risk of prostate cancer among white European men [recessive model: GG vs TG + TT, OR=1.21, (95% CI: 1.03, 1.42), P=0.02]. Our results indicate that the GG genotype of the rs6983267 polymorphism will increase individual susceptibility to prostate cancer in white European men.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Oncology ; Cell Biology
研究领域[WOS]	Oncology ; Cell Biology
关键词[WOS]	GENOME-WIDE ASSOCIATION ; COMMON VARIANTS ; SUSCEPTIBILITY LOCI ; SERBIAN POPULATION ; 8Q24 ; METAANALYSIS ; 17Q12 ; MEN
收录类别	SCI
语种	英语
WOS记录号	WOS:000377722300047
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/2906]
专题	天津工业生物技术研究所_结构生物信息学和整合系统生物学实验室宋江宁_期刊论文
作者单位	1.Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China 2.Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China 3.Tongji Univ, Res Ctr Translat Med, Sch Med, East Hosp, Shanghai 200092, Peoples R China 4.Rice Univ, Dept Stat, Houston, TX 77251 USA 5.Anhui Agr Univ, Sch Sci, Dept Biostat, Hefei, Peoples R China 6.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin, Peoples R China 7.Northwest A&F Univ, Coll Nat Resources & Environm, Yangling, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yuan,Wang, Wenjing,Zhang, Liangcai,et al. Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer[J]. ONCOTARGET,2016,7(18):25528-25534.
APA	Yang, Yuan.,Wang, Wenjing.,Zhang, Liangcai.,Zhang, Shihua.,Liu, Guiyou.,...&Liao, Mingzhi.(2016).Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer.ONCOTARGET,7(18),25528-25534.
MLA	Yang, Yuan,et al."Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer".ONCOTARGET 7.18(2016):25528-25534.