A patterned nanocomposite membrane for high-efficiency healing of diabetic wound | |
Li, Jinyan1,2; Lv, Fang3; Xu, He4; Zhang, Yali2; Wang, Jie4; Yi, Zhengfang3; Yin, Jingbo1; Chang, Jiang2; Wu, Chengtie2 | |
刊名 | JOURNAL OF MATERIALS CHEMISTRY B
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2017 | |
卷号 | 5期号:10页码:1926-1934 |
英文摘要 | The highly efficient therapy of diabetic wounds represents a significant clinical challenge. To effectively stimulate angiogenesis and accelerate diabetic wound healing, we prepared a nanocomposite dressing that combined bioactive glass (BG) nanocoatings with a patterned electrospun membrane (BG/PEM) via a pulsed laser deposition (PLD) technique. The results showed that the BG nanocoatings had a homogeneous nanostructure and uniform elemental distribution including Ca, Si, and P. The surface hydrophilicity of the virgin PEM was significantly improved after the BG nanocoatings were deposited. An in vitro study showed that Si ions could be released from BG/PEM in a controlled profile. The proliferation, attachment, and expression of angiogenesis-related genes (endothelial nitric oxide synthase (eNos) and vascular endothelial growth factor (VEGF)) of human umbilical vein endothelial cells (HUVECs) on BG/PEM were significantly enhanced in comparison with those of the cells on the PEM. An in vivo study showed that diabetic mice wounds treated with BG/PEM had closed by nearly 80% at day 13, which is a significantly higher rate than that obtained with the PEM (57%) and control (56%) groups. Furthermore, wounds treated with BG/PEM displayed significantly improved efficiency in the stimulation of angiogenesis (indicated by CD31 expression and number of new blood vessels), as well as re-epithelialization. Overall, our results indicated that the BG/PEM nanocomposites were promising biomaterials for the rapid stimulation of angiogenesis and highly efficient healing of diabetic wounds. |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Materials Science, Biomaterials |
研究领域[WOS] | Materials Science |
关键词[WOS] | GROWTH-FACTOR ; IN-VITRO ; NANOFIBROUS SCAFFOLDS ; ELECTROSPUN NANOFIBERS ; DRUG-RELEASE ; ANGIOGENESIS ; VIVO ; DRESSINGS ; MODEL ; REGENERATION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000396153000005 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/23579] ![]() |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | 1.Shanghai Univ, Dept Polymer Mat, 333 Nanchen Rd, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.East China Normal Univ, Inst Biomed Sci, Sch Life Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China 4.Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai 200234, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Jinyan,Lv, Fang,Xu, He,et al. A patterned nanocomposite membrane for high-efficiency healing of diabetic wound[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(10):1926-1934. |
APA | Li, Jinyan.,Lv, Fang.,Xu, He.,Zhang, Yali.,Wang, Jie.,...&Wu, Chengtie.(2017).A patterned nanocomposite membrane for high-efficiency healing of diabetic wound.JOURNAL OF MATERIALS CHEMISTRY B,5(10),1926-1934. |
MLA | Li, Jinyan,et al."A patterned nanocomposite membrane for high-efficiency healing of diabetic wound".JOURNAL OF MATERIALS CHEMISTRY B 5.10(2017):1926-1934. |
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