The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces: a systematic study

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces: a systematic study
	Miao, Xinchao 1,2; Wang, Donghui 3,4; Xu, Lianyi 1,2; Wang, Jie 1,2; Zeng, Deliang 1,2; Lin, Shuxian 1,2; Huang, Cui 5,6; Liu, Xuanyong 3; Jiang, Xinquan 1,2
刊名	INTERNATIONAL JOURNAL OF NANOMEDICINE
	2017
卷号	12 页码:1415-1430
关键词	nanotopography osteogenic differentiation soft tissue barrier macrophage polarization antimicrobial effect
英文摘要	Nanotopography modification is a major focus of interest in current titanium surface design; however, the influence of the nanostructured surface on human cell/bacterium behavior has rarely been systematically evaluated. In this study, a homogeneous nanofiber structure was prepared on a titanium surface (Nano) by alkali-hydrothermal treatment, and the effects of this Nano surface on the behaviors of human MG-63 osteoblasts, human gingival epithelial cells (HGECs) and human gingival fibroblasts (HGFs) were evaluated in comparison with a smooth titanium surface (Smooth) by polishing and a micro-rough titanium surface (Micro) by sandblasting and acid etching. In addition, the impacts of these different surface morphologies on human THP-1 macrophage polarization and Streptococcus mutans attachment were also assessed. Our findings showed that the nanostructured surface enhanced the osteogenic activity of MG-63 cells (Nano=Micro. Smooth) at the same time that it improved the attachment of HGECs (Nano. Smooth. Micro) and HGFs (Nano=Micro. Smooth). Furthermore, the surface with nanotexture did not affect macrophage polarization (Nano=Micro= Smooth), but did reduce initial bacterial adhesion (Nano. Smooth. Micro). These results suggest that the nanostructured titanium surface may promote bone and soft tissue healing, and thereby increase the success and survival of dental implants.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
研究领域[WOS]	Science & Technology - Other Topics ; Pharmacology & Pharmacy
关键词[WOS]	IN-VITRO ; DENTAL IMPLANTS ; BIOFILM FORMATION ; GINGIVAL FIBROBLASTS ; VIVO ; ROUGHNESS ; PROTEINS ; OSSEOINTEGRATION ; POLARIZATION ; TOPOGRAPHY
收录类别	SCI
语种	英语
WOS记录号	WOS:000394468400001
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23473]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Stomatol, Dept Prosthodont,Peoples Hosp 9, Beijing, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Stomatol,Peoples Hosp 9, Oral Bioengn Lab,Shanghai Res Inst Stomatol, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Wuhan Univ, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan, Hubei, Peoples R China 6.Wuhan Univ, Sch & Hosp Stomatol, Minist Educ KLOBM, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Miao, Xinchao,Wang, Donghui,Xu, Lianyi,et al. The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces: a systematic study[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:1415-1430.
APA	Miao, Xinchao.,Wang, Donghui.,Xu, Lianyi.,Wang, Jie.,Zeng, Deliang.,...&Jiang, Xinquan.(2017).The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces: a systematic study.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,1415-1430.
MLA	Miao, Xinchao,et al."The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces: a systematic study".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):1415-1430.