Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室

	Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging
	Wei S 1,2; Hua HR 3; Li SQ 3; Li F[]3; Li JL[]1,5; Chen QQ 1; Zhang Y 1; Chen F 1,4
刊名	Zoological Research
	2017
卷号	38 期号:2 页码:96-102
关键词	Tree shrew DNA demethylation 5- hydroxymethylcytosine Brain development and aging
通讯作者	leefan623@sina.com ; lijiali@mail.kiz.ac.cn
英文摘要	Brain development and aging are associated with alterations in multiple epigenetic systems, including DNA methylation and demethylation patterns. Here, we observed that the levels of the 5-hydroxymethylcytosine (5hmC) ten-eleven translocation (TET) enzyme-mediated active DNA demethylation products were dynamically changed and involved in postnatal brain development and aging in tree shrews (Tupaia belangeri chinensis). The levels of 5hmC in multiple anatomic structures showed a gradual increase throughout postnatal development, whereas a significant decrease in 5hmC was found in several brain regions in aged tree shrews, including in the prefrontal cortex and hippocampus, but not the cerebellum. Active changes in Tet mRNA levels indicated that TET2 and TET3 predominantly contributed to the changes in 5hmC levels. Our findings provide new insight into the dynamic changes in 5hmC levels in tree shrew brains during postnatal development and aging processes.
收录类别	其他
资助信息	This work was supported by the Hundred-Talent Program of Chinese Academy of Sciences (Y406541141; 1100050210) to J.L., the National Natural Science Foundation of China (81471313; 91649119) to J.L., the National Science and Technology Infrastructure Program (2014BAI01B01-04) to S.L., and the National Natural Science Foundation of China (31260242 to) F.L.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11032]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_表观遗传与神经退行性疾病
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming Yunnan 650223, China 3.Department of Pathology and Pathophysiology, School of Basic Medical Science, Kunming Medical University, Kunming Yunnan 650500, China 4.School of Life Science, University of Science and Technology of China, Hefei Anhui 230027, China 5.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China
推荐引用方式 GB/T 7714	Wei S,Hua HR,Li SQ,et al. Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging[J]. Zoological Research,2017,38(2):96-102.
APA	Wei S.,Hua HR.,Li SQ.,Li F[].,Li JL[].,...&Chen F.(2017).Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging.Zoological Research,38(2),96-102.
MLA	Wei S,et al."Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging".Zoological Research 38.2(2017):96-102.