Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy

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	Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy
	Shao, Leihou 1,3; Zhang, Ruirui 2; Lu, Jianqing 1,3; Zhao, Caiyan 1,3; Deng, Xiongwei 1,3; Wu, Yan 1,3
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017-01-18
卷号	9 期号:2 页码:1226-1236
关键词	polydopamine mesoporous silica reduced graphene oxide drug delivery chemo-photothermal therapy
ISSN号	1944-8244
英文摘要	The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monotherapy. This work presents a novel nanoplatform which could load chemotherapy drugs with high efficiency and be used as light-mediated photothermal cancer therapy agent.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science
关键词[WOS]	OVERCOME DRUG-RESISTANCE ; IN-VIVO ; CANCER-THERAPY ; COMBINATION THERAPY ; SURFACE-CHEMISTRY ; NANO-GRAPHENE ; NANOPARTICLES ; DELIVERY ; NANOMATERIALS ; DOXORUBICIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000392458300009
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/21898]
专题	过程工程研究所_湿法冶金清洁生产技术国家工程实验室
作者单位	1.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Ctr Excellence Nanosci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing Key Lab Ion Liquids Clean Proc, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Shao, Leihou,Zhang, Ruirui,Lu, Jianqing,et al. Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(2):1226-1236.
APA	Shao, Leihou,Zhang, Ruirui,Lu, Jianqing,Zhao, Caiyan,Deng, Xiongwei,&Wu, Yan.(2017).Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,9(2),1226-1236.
MLA	Shao, Leihou,et al."Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 9.2(2017):1226-1236.