rBMSC and bacterial responses to isoelastic carbon fiber-reinforced poly(ether-ether-ketone) modified by zirconium implantation | |
Li, Jian; Qian, Shi; Ning, Congqin; Liu, Xuanyong | |
刊名 | JOURNAL OF MATERIALS CHEMISTRY B
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2016 | |
卷号 | 4期号:1页码:96-104 |
英文摘要 | PEEK-based biomaterials have great potential applications as hard tissue substitutes in bone tissue engineering. However, inherent bio-inert properties limited their clinical use. In order to improve the bioactivity, in this work, zirconium ions were implanted into the carbon fiber-reinforced PEEK (CFR-PEEK) using plasma immersion ion implantation (PIII) technology. Surface morphologies and chemical compositions of Zr-PIII treated samples were analyzed by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), respectively. The results indicated that nanostructures and ZrO2 nanoparticles were formed on the surface of CFR-PEEK after Zr-PIII. Mechanical tests revealed that nanohardness, elastic modulus, and elastic resistance increased after implantation, especially for the elastic modulus with a maximum value of about 14 GPa, which is much close to that of human natural bone. In vitro cellular experiments showed that Zr-PIII treated samples enhanced the initial adhesion of rBMSCs, spreading and proliferation significantly. Moreover, the heightened ALP activity, collagen secretion, and extracellular matrix mineralization suggested that Zr-PIII treatment could greatly lead to an up-regulated osteogenic differentiation of rBMSCs on CFR-PEEK. In addition, antibacterial properties were also investigated and the results showed that Zr-PIII treated CFR-PEEK with nanostructures exhibited obvious antibacterial activity against S. aureus but no effect on E. coli. |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Materials Science, Biomaterials |
研究领域[WOS] | Materials Science |
关键词[WOS] | POLY(ETHER ETHER KETONE) ; CATHODIC ARC DEPOSITION ; IN-VITRO ; SURFACE MODIFICATION ; BACILLUS-SUBTILIS ; POLYMER SURFACES ; HYDROXYL-GROUPS ; NANO-MGO ; BIOACTIVITY ; POLYETHERETHERKETONE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000366825900009 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/23303] ![]() |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Jian,Qian, Shi,Ning, Congqin,et al. rBMSC and bacterial responses to isoelastic carbon fiber-reinforced poly(ether-ether-ketone) modified by zirconium implantation[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(1):96-104. |
APA | Li, Jian,Qian, Shi,Ning, Congqin,&Liu, Xuanyong.(2016).rBMSC and bacterial responses to isoelastic carbon fiber-reinforced poly(ether-ether-ketone) modified by zirconium implantation.JOURNAL OF MATERIALS CHEMISTRY B,4(1),96-104. |
MLA | Li, Jian,et al."rBMSC and bacterial responses to isoelastic carbon fiber-reinforced poly(ether-ether-ketone) modified by zirconium implantation".JOURNAL OF MATERIALS CHEMISTRY B 4.1(2016):96-104. |
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