Alkaline biodegradable implants for osteoporotic bone defects-importance of microenvironment pH

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	Alkaline biodegradable implants for osteoporotic bone defects-importance of microenvironment pH
	Liu, W.1,2; Wang, T.2; Yang, C.3; Darvell, B. W.4; Wu, J.1; Lin, K.5; Chang, J.5; Pan, H.2; Lu, W. W.1
刊名	OSTEOPOROSIS INTERNATIONAL
	2016
卷号	27 期号:1 页码:93-104
关键词	Bone remodeling In vivo microenvironment pH Orthopaedic biomaterials Osteoporotic bone defect
英文摘要	A Summary Change of microenvironment pH by biodegradable implants may ameliorate unbalanced osteoporotic bone remodeling. The present work demonstrated that a weak alkaline condition stimulated osteoblasts differentiation while suppressed osteoclast generation. In vivo, implants with an alkaline microenvironment pH (monitored by a pH microelectrode) exhibited a promising healing effect for the repair of osteoporotic bone defects.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Endocrinology & Metabolism
研究领域[WOS]	Endocrinology & Metabolism
关键词[WOS]	IN-VIVO ; BIOMATERIALS ; OSTEOBLASTS ; OSTEOCLAST ; CELLS ; MICROELECTRODES ; MINERALIZATION ; FRACTURES ; VITRO ; RAT
收录类别	SCI
语种	英语
WOS记录号	WOS:000369525500012
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23260]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	1.Univ Hong Kong, Fac Med, Dept Orthopaed & Traumatol, Pokfulam, Hong Kong, Peoples R China 2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen Key Lab Marine Biomed Mat, Shenzhen, Peoples R China 3.Shenzhen Univ, Sch Med, Shenzhen 518052, Peoples R China 4.Kuwait Univ, Fac Dent, Dept Bioclin Sci, Dent Mat Sci, Kuwait, Kuwait 5.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Liu, W.,Wang, T.,Yang, C.,et al. Alkaline biodegradable implants for osteoporotic bone defects-importance of microenvironment pH[J]. OSTEOPOROSIS INTERNATIONAL,2016,27(1):93-104.
APA	Liu, W..,Wang, T..,Yang, C..,Darvell, B. W..,Wu, J..,...&Lu, W. W..(2016).Alkaline biodegradable implants for osteoporotic bone defects-importance of microenvironment pH.OSTEOPOROSIS INTERNATIONAL,27(1),93-104.
MLA	Liu, W.,et al."Alkaline biodegradable implants for osteoporotic bone defects-importance of microenvironment pH".OSTEOPOROSIS INTERNATIONAL 27.1(2016):93-104.