Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery
	Ding, Guan-Jun; Zhu, Ying-Jie; Cheng, Guo-Feng; Ruan, Yin-Jie; Qi, Chao; Lu, Bing-Qiang; Chen, Feng; Wu, Jin
刊名	CURRENT NANOSCIENCE
	2016
卷号	12 期号:1 页码:70-78
关键词	Amorphous materials calcium phosphate casein drug delivery nanocomposite nanostructures.
英文摘要	Porous microspheres of casein/amorphous calcium phosphate nanocomposite are prepared using casein sodium salt, CaCl2, Na2HPO4 center dot 12H(2)O and NaH2PO4 center dot 2H(2)O in aqueous solution at room temperature. The effects of experimental parameters such as solution pH, casein sodium salt and ageing time on the product are investigated. Porous microspheres of casein/amorphous calcium phosphate nanocomposite are characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric (TG) analysis, and Brunauer-Emmett-Teller (BET) specific surface area and pore size distribution. The as-prepared porous microspheres of casein/amorphous calcium phosphate nanocomposite are favorable for drug loading and release using ibuprofen (IBU), docetaxel (Dtxl) and vitamin B5 (B5) as typical drugs, and show low cytotoxicity in the cytotoxicity test. Thus, porous microspheres of casein/amorphous calcium phosphate nanocomposite have promising applications in various biomedical fields such as drug delivery.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology
类目[WOS]	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]	ASSISTED HYDROTHERMAL SYNTHESIS ; CASEIN PHOSPHOPEPTIDES ; HYDROXYAPATITE ; PROTEIN ; SYSTEMS ; FLUTAMIDE ; MICELLES ; RELEASE ; NUTRACEUTICALS ; NANOPARTICLES
收录类别	SCI
语种	英语
WOS记录号	WOS:000372112600009
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23154]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Ding, Guan-Jun,Zhu, Ying-Jie,Cheng, Guo-Feng,et al. Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery[J]. CURRENT NANOSCIENCE,2016,12(1):70-78.
APA	Ding, Guan-Jun.,Zhu, Ying-Jie.,Cheng, Guo-Feng.,Ruan, Yin-Jie.,Qi, Chao.,...&Wu, Jin.(2016).Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery.CURRENT NANOSCIENCE,12(1),70-78.
MLA	Ding, Guan-Jun,et al."Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery".CURRENT NANOSCIENCE 12.1(2016):70-78.