Templated solvothermal synthesis of magnesium silicate hollow nanospheres with ultrahigh specific surface area and their application in high-performance protein adsorption and drug delivery | |
Sun, Tuan-Wei; Zhu, Ying-Jie; Qi, Chao; Chen, Feng; Jiang, Ying-Ying; Zhang, Yong-Gang; Wu, Jin; Wu, Chengtie | |
刊名 | JOURNAL OF MATERIALS CHEMISTRY B
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2016 | |
卷号 | 4期号:19页码:3257-3268 |
英文摘要 | Magnesium silicate nanostructured biomaterials with good biocompatibility and high adsorption capacity for drugs and proteins are promising for applications in various biomedical fields. However, the applications of magnesium silicate nanostructured biomaterials in anticancer drug delivery and protein adsorption have rarely been reported so far. Herein, we report a facile strategy for the synthesis of magnesium silicate hollow nanospheres (MSHNSs) by a classical Stober method and a template based solvothermal process. The as-prepared MSHNSs have an ultrahigh specific surface area of 585.6 m(2) g(-1), ultrahigh hemoglobin (Hb) protein adsorption capacity (1262 mg g(-1)) and high doxorubicin (DOX) drug loading capacity (559 mg g(-1)). Moreover, the as-prepared MSHNS/DOX drug delivery system exhibits sustained and pH-responsive drug release performance. Compared with free DOX, the MSHNS/DOX drug delivery system exhibits higher anticancer activity in vitro, and thus it is promising for applications in anticancer treatment. |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Materials Science, Biomaterials |
研究领域[WOS] | Materials Science |
关键词[WOS] | ASSISTED RAPID SYNTHESIS ; ORGANIC PHOSPHORUS SOURCE ; CREATINE-PHOSPHATE ; HYDRATE NANOSHEETS ; MESOPOROUS SILICA ; BOVINE HEMOGLOBIN ; BONDING STRENGTH ; URANYL IONS ; METAL-IONS ; LEAD IONS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000376039100010 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/23075] ![]() |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Tuan-Wei,Zhu, Ying-Jie,Qi, Chao,et al. Templated solvothermal synthesis of magnesium silicate hollow nanospheres with ultrahigh specific surface area and their application in high-performance protein adsorption and drug delivery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(19):3257-3268. |
APA | Sun, Tuan-Wei.,Zhu, Ying-Jie.,Qi, Chao.,Chen, Feng.,Jiang, Ying-Ying.,...&Wu, Chengtie.(2016).Templated solvothermal synthesis of magnesium silicate hollow nanospheres with ultrahigh specific surface area and their application in high-performance protein adsorption and drug delivery.JOURNAL OF MATERIALS CHEMISTRY B,4(19),3257-3268. |
MLA | Sun, Tuan-Wei,et al."Templated solvothermal synthesis of magnesium silicate hollow nanospheres with ultrahigh specific surface area and their application in high-performance protein adsorption and drug delivery".JOURNAL OF MATERIALS CHEMISTRY B 4.19(2016):3257-3268. |
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