Oxidative stress-mediated selective antimicrobial ability of nano-VO2 against Gram-positive bacteria for environmental and biomedical applications | |
Li, Jinhua1,2; Zhou, Huaijuan1,2; Wang, Jiaxing3; Wang, Donghui1,2; Shen, Ruxiang1; Zhang, Xianlong3; Jin, Ping1,4; Liu, Xuanyong1 | |
刊名 | NANOSCALE
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2016 | |
卷号 | 8期号:23页码:11907-11923 |
英文摘要 | Vanadium dioxide (VO2) is a unique thermochromic material as a result of its semiconductor-metal transition, holding great promise for energy-saving intelligent windows. Herein, pure nano-VO2 from discrete nanoparticles to continuous films were successfully deposited on quartz glass by controlling the sputtering parameters. It was demonstrated that, for Gram-positive S. aureus and S. epidermidis, the nano-VO2 could effectively disrupt bacteria morphology and membrane integrity, and eventually cause death. By contrast, the nano-VO2 did not exhibit significant toxicity towards Gram-negative E. coli and P. aeruginosa. To our knowledge, this is the first report on a selective antimicrobial effect of nano-VO2 materials on Gram-positive bacteria. Based on the experimental results, a plausible mechanism was proposed for the antimicrobial selectivity, which might originate from the different sensitivity of Gram-positive and Gram-negative bacteria to intracellular reactive oxygen species (ROS) level. Elevated intracellular ROS levels exceed the threshold that bacteria can self-regulate to maintain cellular redox homeostasis and thus cause oxidative stress, which can be alleviated by the intervention of glutathione (GSH) antioxidant. In addition, nano-VO2 did not produce significant cytotoxicity (hemolysis) against human erythrocytes within 12 h. Meanwhile, potential cytotoxicity against HIBEpiC revealed a time-and dose-dependent behavior that might be controlled and balanced by careful design. The findings in the present work may contribute to understanding the antimicrobial behavior of nano-VO2, and to expanding the new applications of VO2-based nanomaterials in environmental and biomedical fields. |
WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
类目[WOS] | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
关键词[WOS] | LIPID-PEROXIDATION ; ANTIBACTERIAL ACTIVITY ; VANADIUM COMPOUNDS ; ESCHERICHIA-COLI ; TOXICITY ; CELLS ; SYSTEMS ; NANOPARTICLES ; GLUTATHIONE ; MEMBRANE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000378510700018 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/22936] ![]() |
专题 | 上海硅酸盐研究所_古陶瓷与工业陶瓷工程研究中心_期刊论文 |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Jiao Tong Univ, Dept Orthopaed, Peoples Hosp 6, Shanghai 200233, Peoples R China 4.Natl Inst Adv Ind Sci & Technol, Mat Res Inst Sustainable Dev, Nagoya, Aichi 4638560, Japan |
推荐引用方式 GB/T 7714 | Li, Jinhua,Zhou, Huaijuan,Wang, Jiaxing,et al. Oxidative stress-mediated selective antimicrobial ability of nano-VO2 against Gram-positive bacteria for environmental and biomedical applications[J]. NANOSCALE,2016,8(23):11907-11923. |
APA | Li, Jinhua.,Zhou, Huaijuan.,Wang, Jiaxing.,Wang, Donghui.,Shen, Ruxiang.,...&Liu, Xuanyong.(2016).Oxidative stress-mediated selective antimicrobial ability of nano-VO2 against Gram-positive bacteria for environmental and biomedical applications.NANOSCALE,8(23),11907-11923. |
MLA | Li, Jinhua,et al."Oxidative stress-mediated selective antimicrobial ability of nano-VO2 against Gram-positive bacteria for environmental and biomedical applications".NANOSCALE 8.23(2016):11907-11923. |
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