Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion
	Lin, Han 1,2; Wang, Xingang 1; Yu, Luodan 1,2; Chen, Yu 1; Shi, Jianlin 1
刊名	NANO LETTERS
	2017
卷号	17 期号:1 页码:384-391
关键词	Ultrathin MXene Ti3C2 nanosheets nanomedicine photothermal conversion tumor therapy
英文摘要	Ceramic biomaterials have been investigated for several decades, but their potential biomedical applications in cancer therapy have been paid much less attentions, mainly due to their lack of related material functionality for combating the cancer. In this work, we report, for the first time, that MAX ceramic biomaterials exhibit the unique functionality for the photothermal ablation of cancer upon being exfoliated into ultrathin nanosheets within atomic thickness (MXene). As a paradigm, biocompatible Ti3C2 nanosheets (MXenes) were successfully synthesized based on a two-step exfoliation strategy of MAX phase Ti3AlC2 by the combined HF etching and TPAOH intercalation. Especially, the high photothermal-conversion efficiency and in vitro/in vivo photothermal ablation of tumor of Ti3C2 nanosheets (MXenes) were revealed and demonstrated, not only in the intravenous administration of soybean phospholipid modified Ti3C2 nanosheets but also in the localized intratumoral implantation of a phase-changeable PLGA/Ti3C2 organic-inorganic hybrid. This work promises the great potential of Ti3C2 nanosheets (MXenes) as a novel ceramic photothermal agent used for cancer therapy and may arouse much interest in exploring MXene-based ceramic biomaterials to benefit the biomedical applications.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	HIGH VOLUMETRIC CAPACITANCE ; IN-VIVO ; TITANIUM CARBIDE ; DRUG-DELIVERY ; CANCER-CELLS ; THERAPY ; GRAPHENE ; NANOPARTICLES ; NANOCRYSTALS ; MOS2
收录类别	SCI
语种	英语
WOS记录号	WOS:000392036600055
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23375]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lin, Han,Wang, Xingang,Yu, Luodan,et al. Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion[J]. NANO LETTERS,2017,17(1):384-391.
APA	Lin, Han,Wang, Xingang,Yu, Luodan,Chen, Yu,&Shi, Jianlin.(2017).Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion.NANO LETTERS,17(1),384-391.
MLA	Lin, Han,et al."Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion".NANO LETTERS 17.1(2017):384-391.