PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging
	Ni, Dalong 1; Zhang, Jiawen 2; Bu, Wenbo 1; Zhang, Chen 1; Yao, Zhenwei 1; Xing, Huaiyong 1; Wang, Jing 2; Duan, Fei 2; Liu, Yanyan 1; Fan, Wenpei 1
刊名	BIOMATERIALS
	2016
卷号	76 页码:218-225
关键词	Dual-modality imaging CT Ultra-high field MRI Relaxivity mechanism Holmium
英文摘要	It is well-known that multimodal imaging can integrate the advantages of different imaging modalities by overcoming their individual limitations. As ultra-high field magnetic resonance imaging (MRI) will be inevitably used in future MRI/X-ray computed tomography (CT) scanner, it is highly expected to develop high-performance nano-contrast agents for ultra-high field MR and CT dual-modality imaging, which has not been reported yet. Moreover, specific behavior of nano-contrast agents for ultra-high field MM is a challenging work and still remains unknown. Herein, a novel type of NaHOF4 nanoparticles (NPs) with varied particle sizes were synthesized and explored as high-performance dual-modality contrast agents for ultra-high field MR and CT imaging. The specific X-ray absorption and MR relaxivity enhancements with varied nanoparticle diameters (3 nm, 7 nm, 13 nm and 29 nm) under different magnetic field (1.5/3.0/7.0 T) are investigated. Based on experimental results and theoretical analysis, the Curie and dipolar relaxation mechanisms of NaHOF4 NPs are firstly separated. Our results will greatly promote the future medical translational development of the NaHOF4 nano-contrast agents for ultra-high field MR/CT dualmodality imaging applications. (c) 2015 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	QUANTUM DOTS ; MRI ; PERFORMANCE ; THERAPY ; CT ; SIZE ; NANOCRYSTALS ; ANGIOGRAPHY ; RELAXATION ; NANOPROBES
收录类别	SCI
语种	英语
WOS记录号	WOS:000366961100018
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23337]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China
推荐引用方式 GB/T 7714	Ni, Dalong,Zhang, Jiawen,Bu, Wenbo,et al. PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging[J]. BIOMATERIALS,2016,76:218-225.
APA	Ni, Dalong.,Zhang, Jiawen.,Bu, Wenbo.,Zhang, Chen.,Yao, Zhenwei.,...&Shi, Jianlin.(2016).PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging.BIOMATERIALS,76,218-225.
MLA	Ni, Dalong,et al."PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging".BIOMATERIALS 76(2016):218-225.