On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles | |
Fan, Wenpei1,2; Bu, Wenbo1,3; Shi, Jianlin1 | |
刊名 | ADVANCED MATERIALS
![]() |
2016-06-01 | |
卷号 | 28期号:21页码:3987-4011 |
英文摘要 | Following the "detect-to-treat" strategy, by biological engineering, the emerging upconversion nanoparticles (UCNPs) have become one of the most promising inorganic nanomedicines, and their biomedical applications have gradually shifted from multimodal tumor imaging to highly efficient cancer therapy. The past few years have witnessed a three-stage development of UCNP-based nanomedicines. On one hand, UCNPs can optimize each clinical treatment tool (chemotherapy, photodynamic therapy (PDT), radiotherapy (RT)) by controlled drug delivery/release, near-infrared (NIR)-excited deep PDT, and radiosensitization, respectively, all of which contribute greatly to the optimized treatment efficacy along with minimized side effects. On the other hand, several individual treatments can be "smartly" integrated into a single UCNP-based nanotheranostic system for multimodal synergetic therapy, which can further improve the overall therapeutic effectiveness. Especially, UCNPs provide more-effective strategies for overcoming tumor hypoxia, thus leading to an ideal treatment efficacy for complete eradication of solid tumors. Finally, the critical issues regarding the future development of UCNPs are discussed to promote the clinic-translational applications of UCNP-based nanomedicines, as well as realization of our "one drug fits all" dream. |
WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
关键词[WOS] | NEAR-INFRARED LIGHT ; MESOPOROUS SILICA NANOPARTICLES ; RAY COMPUTED-TOMOGRAPHY ; VIVO PHOTODYNAMIC THERAPY ; TARGETED PHOTOTHERMAL THERAPY ; INTRANUCLEAR DRUG-DELIVERY ; CORE-SHELL NANOPARTICLES ; IN-VIVO ; X-RAY ; UPCONVERTING NANOPARTICLES |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000377122400001 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/22986] ![]() |
专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA 3.E China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China |
推荐引用方式 GB/T 7714 | Fan, Wenpei,Bu, Wenbo,Shi, Jianlin. On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles[J]. ADVANCED MATERIALS,2016,28(21):3987-4011. |
APA | Fan, Wenpei,Bu, Wenbo,&Shi, Jianlin.(2016).On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles.ADVANCED MATERIALS,28(21),3987-4011. |
MLA | Fan, Wenpei,et al."On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles".ADVANCED MATERIALS 28.21(2016):3987-4011. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论