Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines
	Liu, Lihong; Zhang, Yu; Yun, Zhaojun; He, Bin; Jiang, Guibin
刊名	JOURNAL OF ENVIRONMENTAL SCIENCES
	2016-01
卷号	39 期号:0 页码:37-44
关键词	Bioaccessibility Mercury Chinese patent medicine Simulated digestion extraction
英文摘要	Mercury (Hg), mainly in cinnabar species, has been used in medicine for thousands of years in China, and worldwide concern has been raised on its toxicity. In this work, the amount of bioaccessible mercury in 16 Chinese patent medicines (CPMs) was measured by using an in vitro simulated digestion system, consisting of simulated gastric and intestinal fluid, to investigate the bioavailability of mercury in CPMs and evaluate its potential risk to human health. Total mercury and mercury in the gastrointestinal extracts were measured by inductively coupled plasma mass spectrometry (ICP-MS). The levels of total Hg in 16 CPMs ranged from not detected to 11.89 mu g/g, with a mean value of 1.13 mu g/g, while the extractable Hg ranged from not detected to 4.37 mu g/g, with a mean value of 0.42 mu g/g. Mercury bioaccessibility varied significantly in the investigated CPMs, depending on the ingredient. Compared to the CPMs without cinnabar (2.5%-30.9%), the percentage of mercury in the gastrointestinal supernatants for CPMs with cinnabar was quite a bit lower (0.037%). By comparing with the Food and Agricultural Organization/World Health Organization Joint Expert Committee on Food Additives (FAO/WHO) safety guideline, the average daily intake dose (ADD) of Hg in the medicines was then calculated to access the risk of mercury to human health from taking CPMs. (C) 2015 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
收录类别	SCI
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/35851]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Liu, Lihong,Zhang, Yu,Yun, Zhaojun,et al. Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2016,39(0):37-44.
APA	Liu, Lihong,Zhang, Yu,Yun, Zhaojun,He, Bin,&Jiang, Guibin.(2016).Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines.JOURNAL OF ENVIRONMENTAL SCIENCES,39(0),37-44.
MLA	Liu, Lihong,et al."Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines".JOURNAL OF ENVIRONMENTAL SCIENCES 39.0(2016):37-44.