Inositol transporters AtINT2 and AtINT4 regulate arsenic accumulation in Arabidopsis seeds

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 城市与区域生态国家重点实验室

	Inositol transporters AtINT2 and AtINT4 regulate arsenic accumulation in Arabidopsis seeds
	Duan, Gui-Lan; Hu, Ying; Schneider, Sabine; McDermott, Joseph; Chen, Jian; Sauer, Norbert; Rosen, Barry P.; Daus, Birgit; Liu, Zijuan; Zhu, Yong-Guan
刊名	NATURE PLANTS
	2016-01
卷号	2 期号:1 页码:-
英文摘要	Arsenic contamination of groundwater and soils threatens the health of tens of millions of people worldwide. Understanding the way in which arsenic is taken up by crops such as rice, which serve as a significant source of arsenic in the human diet, is therefore important. Membrane transport proteins that catalyse arsenic uptake by roots, and translocation through the xylem to shoots, have been characterized in a number of plants, including rice. The transporters responsible for loading arsenic from the xylem into the phloem and on into the seeds, however, are yet to be identified. Here, we show that transporters responsible for inositol uptake in the phloem in Arabidopsis also transport arsenic. Transformation of Saccharomyces cerevisiae with AtINT2 or AtINT4 led to increased arsenic accumulation and increased sensitivity to arsenite. Expression of AtINT2 in Xenopus laevis oocytes also induced arsenite import. Disruption of AtINT2 or AtINT4 in Arabidopsis thaliana led to a reduction in phloem, silique and seed arsenic concentrations in plants fed with arsenite through the roots, relative to wild-type plants. These plants also exhibited a large drop in silique and seed arsenic concentrations when fed with arsenite through the leaves. We conclude that in Arabidopsis, inositol transporters are responsible for arsenite loading into the phloem, the key source of arsenic in seeds.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/35608]
专题	生态环境研究中心_城市与区域生态国家重点实验室
推荐引用方式 GB/T 7714	Duan, Gui-Lan,Hu, Ying,Schneider, Sabine,et al. Inositol transporters AtINT2 and AtINT4 regulate arsenic accumulation in Arabidopsis seeds[J]. NATURE PLANTS,2016,2(1):-.
APA	Duan, Gui-Lan.,Hu, Ying.,Schneider, Sabine.,McDermott, Joseph.,Chen, Jian.,...&Zhu, Yong-Guan.(2016).Inositol transporters AtINT2 and AtINT4 regulate arsenic accumulation in Arabidopsis seeds.NATURE PLANTS,2(1),-.
MLA	Duan, Gui-Lan,et al."Inositol transporters AtINT2 and AtINT4 regulate arsenic accumulation in Arabidopsis seeds".NATURE PLANTS 2.1(2016):-.