Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation
	Zhang, Ruowen 1; Che, Xun 1; Zhang, Jingjie 1; Li, Yang 1,3; Li, Jingxia 1; Deng, Xu2 ; Zhu, Junlan 1,3; Jin, Honglei 3; Zhao, Qinshi2 ; Huang, Chuanshu 1
刊名	ONCOTARGET
	2016-10-11
卷号	7 期号:41 页码:66689-66699
关键词	Chel A human bladder cancer apoptosis PHLPP2 c-Jun
英文摘要	Cheliensisin A (Chel A), a styryl-lactone compound extracted from Goniothalamus cheliensis, is reported to have significant anti-cancer effects in various cancer cells. Here we demonstrated that Chel A treatment resulted in apoptosis and an inhibition of anchorage-independent growth in human bladder cancer T24, T24T and U5637 cells. Mechanistic studies showed that such effect is mediated by PH domain and Leucine rich repeat Protein Phosphatases (PHLPP2) protein. Chel A treatment led to PHLPP2 degradation and subsequently increased in c-Jun phosphorylation. Moreover PHLPP2 degradation could be attenuated by inhibition of autophagy, which was mediated by Beclin 1. Collectively, we discover that Chel A treatment induces Beclin-dependent autophagy, consequently mediates PHLPP2 degradation and JNK/C-Jun phosphorylation and activation, further in turn contributing to apoptosis in human bladder cancer cells. Current studies provide a significant insight into understanding of anticancer effect of Chel A in treatment of human bladder cancer.
类目[WOS]	Oncology ; Cell Biology
研究领域[WOS]	Oncology ; Cell Biology
关键词[WOS]	NF-KAPPA-B ; C-JUN ; BEAS-2B CELLS ; INDUCTION ; EXPRESSION ; ARSENITE ; PATHWAY ; EPIDEMIOLOGY ; JNK1
收录类别	SCI
语种	英语
WOS记录号	WOS:000387446200029
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/33660]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Wenzhou Med Univ, Sch Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ruowen,Che, Xun,Zhang, Jingjie,et al. Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation[J]. ONCOTARGET,2016,7(41):66689-66699.
APA	Zhang, Ruowen.,Che, Xun.,Zhang, Jingjie.,Li, Yang.,Li, Jingxia.,...&Huang, Chuanshu.(2016).Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation.ONCOTARGET,7(41),66689-66699.
MLA	Zhang, Ruowen,et al."Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation".ONCOTARGET 7.41(2016):66689-66699.