A novel photoacoustic nanoprobe of ICG@PEG-Ag2S for atherosclerosis targeting and imaging in vivo

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 王强斌团队

	A novel photoacoustic nanoprobe of ICG@PEG-Ag2S for atherosclerosis targeting and imaging in vivo
	Wu, CX(巫晨昕); Zhang, YJ(张叶俊); Li, Z; Li, CY(李春炎); Wang, QB(王强斌)
刊名	NANOSCALE
	2016
卷号	8 期号:25
通讯作者	Li, CY(李春炎) ; Wang, QB(王强斌)
英文摘要	Atherosclerosis is a major cause of cardiovascular and cerebrovascular diseases that have high mortality and disability rates. Because of its unclear pathogenic mechanism and heterogeneous distribution feature, it is still a big challenge to achieve precise diagnosis and therapy of atherosclerosis at its early stage in vivo. Herein, we fabricated a new ICG@PEG-Ag2S nanoprobe by a simple selfassembly of DT-Ag2S QDs, amphipathic C18/PEG polymer molecules and ICG. The ICG@PEG-Ag2S nanoprobe showed relatively long blood retention and was selectively accumulated in the region of atherosclerotic plaque due to the lipophilicity of the C18 chain to the atherosclerosis microenvironment, and thus the atherosclerosis was real-time monitored by high contrastenhanced photoacoustic (PA) imaging of ICG. Combining the high signal-to-noise ratio (SNR) and high spatial resolution fluorescence imaging of Ag2S QDs in the second near-infrared window (NIR-II) and related histological assessment in vitro, the feasibility of this new nanoprobe for atherosclerosis targeting in an Apoe(-/-) mouse model was verified. Additionally, hemolysis and coagulation assays of the ICG@PEG-Ag2S revealed its decent hemocompatibility and no histological changes were observed in the main organs of the mouse. Such a simple, multifunctional nanoprobe for targeting and PA imaging of atherosclerosis will have a great potential for future clinical applications.
关键词[WOS]	NEAR-INFRARED WINDOW ; AG2S QUANTUM DOTS ; INDOCYANINE GREEN ; VISUALIZATION ; NANOPARTICLES ; FLUORESCENCE ; INFLAMMATION ; THERAPY ; TOMOGRAPHY ; TUMORS
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000378722100011
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/4639]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_王强斌团队
推荐引用方式 GB/T 7714	Wu, CX,Zhang, YJ,Li, Z,et al. A novel photoacoustic nanoprobe of ICG@PEG-Ag2S for atherosclerosis targeting and imaging in vivo[J]. NANOSCALE,2016,8(25).
APA	Wu, CX,Zhang, YJ,Li, Z,Li, CY,&Wang, QB.(2016).A novel photoacoustic nanoprobe of ICG@PEG-Ag2S for atherosclerosis targeting and imaging in vivo.NANOSCALE,8(25).
MLA	Wu, CX,et al."A novel photoacoustic nanoprobe of ICG@PEG-Ag2S for atherosclerosis targeting and imaging in vivo".NANOSCALE 8.25(2016).