Coassembly of Tobacco Mosaic Virus Coat Proteins into Nanotubes with Uniform Length and Improved Physical Stability

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 王强斌团队

	Coassembly of Tobacco Mosaic Virus Coat Proteins into Nanotubes with Uniform Length and Improved Physical Stability
	Zhou, K(周堃); Eiben, S; Wang, QB(王强斌)
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016
卷号	8 期号:21 页码:13192-13196
关键词	chimerical scaffold coassembly disulfide bond length-controllability physical stabilization tobacco mosaic virus
通讯作者	Wang, QB(王强斌)
英文摘要	Using tobacco mosaic virus coat proteins (TMVcp) from both sources of the plant and bacterial expression systems as building blocks, we demonstrate here a coassembly strategy of TMV nanotubes in the presence of RNA. Specifically, plant-expressed cp (cp(p)) efficiently dominates the genomic RNA encapsidation to determine the length of assembled TMV nanotubes, whereas the incorporated Escherichia coli-expressed cp (cp(ec)) improves the physical stability of TMV nanotubes by introducing disulfide bonds between the interfaces of subunits. We expect this coassembly strategy can be expanded to other virus nanomaterials to obtain desired properties based on rationally designed protein-RNA and protein-protein interfacial interactions.
关键词[WOS]	NANOSTRUCTURES ; NANORODS ; RNA ; BIOTECHNOLOGY ; NANOPARTICLES ; NANOMATERIALS ; INTEGRATION ; PARTICLES ; PEPTIDES ; DISPLAY
收录类别	SCI
语种	英语
WOS记录号	WOS:000377150400003
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/4533]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_王强斌团队
推荐引用方式 GB/T 7714	Zhou, K,Eiben, S,Wang, QB. Coassembly of Tobacco Mosaic Virus Coat Proteins into Nanotubes with Uniform Length and Improved Physical Stability[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(21):13192-13196.
APA	Zhou, K,Eiben, S,&Wang, QB.(2016).Coassembly of Tobacco Mosaic Virus Coat Proteins into Nanotubes with Uniform Length and Improved Physical Stability.ACS APPLIED MATERIALS & INTERFACES,8(21),13192-13196.
MLA	Zhou, K,et al."Coassembly of Tobacco Mosaic Virus Coat Proteins into Nanotubes with Uniform Length and Improved Physical Stability".ACS APPLIED MATERIALS & INTERFACES 8.21(2016):13192-13196.