Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in an in vitro human co-culture model

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 离职团队

	Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in an in vitro human co-culture model
	Sun, ZL; Yang, LY; Chen, KF; Chen, GW; Peng, YP; Chen, JK; Suo, GL(索广利); Yu, JT; Wang, WC; Lin, CH
刊名	NANOTOXICOLOGY
	2016
卷号	10 期号:7
通讯作者	Wang, WC ; Lin, CH
英文摘要	Despite promising environmental applications for nano zerovalent iron (nZVI), concerns remain about the potential accumulation and toxic effects of nZVI particles. Here, we use an alveolar-capillary co-culture model to investigate a possible link between low-level epithelial exposure to nZVI and pulmonary and cardiovascular toxicity. While nZVI was unable to pass through the epithelial barrier into the endothelium, nZVI exposure did cause oxidative and inflammatory responses in both epithelial and endothelial cells. Therefore, toxic effects induced by nZVI are not restricted to epithelial cells but can be transferred into the endothelium. Communication between A549 and EA.hy926 cells is responsible for amplification of nZVI-induced toxic responses. Decreases in transepithelial electrical resistance and zonula occludens proteins after epithelial exposure to nZVI impaired epithelial barrier integrity. Increases in oxidized 1-antitrypsin and oxidized low-density lipoprotein in the co-culture model suggest that nZVI exposure increases the risk of chronic obstructive pulmonary disease and atherosclerosis. Therefore, inhalation of nZVI has the potential to induce cardiovascular disease through oxidative and inflammatory mediators produced from the damaged lung epithelium in chronic lung diseases.
关键词[WOS]	ALVEOLAR-CAPILLARY COCULTURE ; BRONCHIAL EPITHELIAL-CELLS ; HUMAN NEUROBLASTOMA-CELLS ; OXIDATIVE STRESS ; QUANTUM DOTS ; ALPHA-1-ANTITRYPSIN DEFICIENCY ; DEVELOPMENTAL TOXICITY ; NANOPARTICLE EXPOSURE ; OXIDE NANOPARTICLES ; DISEASE
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000379248800005
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/4707]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_离职团队
推荐引用方式 GB/T 7714	Sun, ZL,Yang, LY,Chen, KF,et al. Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in an in vitro human co-culture model[J]. NANOTOXICOLOGY,2016,10(7).
APA	Sun, ZL.,Yang, LY.,Chen, KF.,Chen, GW.,Peng, YP.,...&Lin, CH.(2016).Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in an in vitro human co-culture model.NANOTOXICOLOGY,10(7).
MLA	Sun, ZL,et al."Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in an in vitro human co-culture model".NANOTOXICOLOGY 10.7(2016).