Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo-photothermal combination therapy of cancer

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 戴建武团队

	Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo-photothermal combination therapy of cancer
	Wang, X(王新); Zhang, Q(张倩); Zou, L(周璐); Hu, HS(胡慧珊); Zhang, MX(张萌欣); Dai, JW(戴建武)
刊名	RSC ADVANCES
	2016
卷号	6 期号:25
通讯作者	Wang, X(王新) ; Dai, JW(戴建武)
英文摘要	Combinational chemo-photothermal therapy has been considered as a promising strategy to enhance antitumor efficiency via synergistic effects for cancer treatments. Here, we have developed a smart 'all-in-one' platform that conveniently combined chemo-and photothermal therapies based on ultrasmall CuS NCs, which were synthesized using a facile, low cost, and water solution reaction method. Doxorubicin (Dox)-loaded CuS drug nanocarriers (CuS-Dox) were fabricated with loading capacity up to 21%. The resulting CuS-Dox exhibited pH and NIR light dual-responsiveness, demonstrating remarkably promoted Dox release in a weakly acidic environment in cancer cells and enhanced intercellular uptake under 808 nm laser irradiation. Based on in vitro cell cytotoxicity, the CuS-Dox endow excellent chemo-photothermal synergistic effects for cancer cell death or apoptosis, attributed to both the cytotoxicity of light-triggered Dox release and CuS-mediated photothermal ablation. More importantly, in vivo treatment has achieved the complete inhibition of tumor growth in 4T1-bearing mice under a low laser power density of 1.0 W cm(-2). These results demonstrate a better anti-tumor therapeutic efficacy of combined treatment in vitro and in vivo in comparison with chemotherapy or photothermal therapy alone. Our study highlights the promise of fabricating CuS-Dox drug nanocarriers for highly effective chemo-photothermal combination therapy of cancer.
关键词[WOS]	COPPER SULFIDE NANOPARTICLES ; MESOPOROUS SILICA NANOSPHERE ; CORE-SHELL NANOPARTICLES ; GOLD NANORODS ; CONTROLLED-RELEASE ; IN-VIVO ; CONVERSION EFFICIENCY ; DELIVERY SYSTEM ; GRAPHENE OXIDE ; BREAST-CANCER
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000371019000060
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/4663]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_戴建武团队
推荐引用方式 GB/T 7714	Wang, X,Zhang, Q,Zou, L,et al. Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo-photothermal combination therapy of cancer[J]. RSC ADVANCES,2016,6(25).
APA	Wang, X,Zhang, Q,Zou, L,Hu, HS,Zhang, MX,&Dai, JW.(2016).Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo-photothermal combination therapy of cancer.RSC ADVANCES,6(25).
MLA	Wang, X,et al."Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo-photothermal combination therapy of cancer".RSC ADVANCES 6.25(2016).