The possible involvement of tissue type plasminogen activator in luteolysis of rhesus monkey

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	The possible involvement of tissue type plasminogen activator in luteolysis of rhesus monkey
	Feng Q 1,3; Liu K 1; Liu YX[*]1; Hu ZY 1; Zou R 2; Yang SC 2
刊名	HUMAN REPRODUCTION
	1993
卷号	8 期号:10 页码:1640-1644
关键词	LUTEOLYSIS RHESUS MONKEY TISSUE TYPE PLASMINOGEN ACTIVATOR
英文摘要	Changes of plasminogen activators (PA) during different stages of development of the corpus luteum, and their possible physiological role in luteolysis were studied in rhesus monkeys. It was demonstrated for the first time that monkey corpus luteal cells not only produce PA, but that the function of the corpus luteum is also closely related to the activity of this enzyme system. Generally, the life span for a corpus luteum in monkey is approximately 14-16 days, its demise beginning thereafter. In the present study, we found that urokinase in the corpus luteum is higher on day 5 and day 10 after human chorionic gonadotrophin injection, while the tissue type (t) PA is mainly produced on day 13 when luteolysis may take place. Progesterone production remained high on day 5 and day 10 and decreased dramatically from day 13, indicating the important role of tPA but not urokinase (u) PA in suppressing luteal function. When purified tPA (but not uPA) monoclonal antibody was added to luteal cell culture to neutralize endogenously produced tPA activity, progesterone production in the cells was increased significantly. Interestingly, prolactin alone was capable of increasing PA production by luteal cells; prolactin together with luteinizing hormone, however, had a synergistic luteotrophic effect.
收录类别	SCI
资助信息	This investigation received financial support from the Task Force for Post-Ovulatory Method, die Special Programme of Research, Development and Research Training in Human Reproduction of the World Health Organization and from the State Family Planning Com- mission.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10923]
专题	昆明动物研究所_其他昆明动物研究所_神经系统编码
作者单位	1.State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PRC 100080 2.Primate Research Centre, Kunming Institute of Zoology, Chinese Academy of Sciences, People's Republic of China 650107 3.Present address: European Community Postdoctoral Fellow, Department of Molecular Cell Biology, University of Copenhagen, 0ster Farimagsgade 2A, DK-1353 Copenhagen K, Denmark
推荐引用方式 GB/T 7714	Feng Q,Liu K,Liu YX[*],et al. The possible involvement of tissue type plasminogen activator in luteolysis of rhesus monkey[J]. HUMAN REPRODUCTION,1993,8(10):1640-1644.
APA	Feng Q,Liu K,Liu YX[*],Hu ZY,Zou R,&Yang SC.(1993).The possible involvement of tissue type plasminogen activator in luteolysis of rhesus monkey.HUMAN REPRODUCTION,8(10),1640-1644.
MLA	Feng Q,et al."The possible involvement of tissue type plasminogen activator in luteolysis of rhesus monkey".HUMAN REPRODUCTION 8.10(1993):1640-1644.