Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室

	Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells
	Li W 1,2; Zhang HX 1,2; Chen CS 4; Liu R[]4; Chen HJ[]5; Nie MX 1,2; Tian YL 1,3; Chen X 1,2
刊名	Acta Biochim Biophys Sin (Shanghai)
	2017
卷号	49 期号:4 页码:367–373
关键词	renal cell carcinoma triple negative breast cancer ursolic acid FZU-03,010 STAT3
通讯作者	liurong@mail.kiz.ac.cn ; chenhaij@gmail.co
英文摘要	Advanced renal cell carcinoma and triple negative breast cancer (TNBC) are malignancies without effective therapeutics currently. Ursolic acid (UA) has been previously reported to have anti-cancer effects in multiple solid tumors. In order to develop more potent anti-cancer reagents, FZU-03,010 based on the chemical structure of UA were synthesized. The results demonstrated that, compared with UA, FZU-03,010 could suppress renal cancer cell 786-0 and TNBC cell HCC1806 cell viability more potently. Furthermore, FZU-03,010 could induce G1 cell cycle arrest and cell apoptosis more efficiently than UA. FZU-03,010 could also inhibit signal transducer and activator of transcription 3 activation, induce the expression of cell cycle-dependent kinase inhibitors (p21 and p27) and promote cell apoptosis. In conclusion, our results suggest that the UA derivative FZU-03,010 is more potent in inhibiting cancer cell survival, and FZU-03,010 has the potential to be developed as a therapeutic for renal cell cancers and TNBCs.
收录类别	其他
资助信息	This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81272930 and 81322038 to R.L.), West Light Foundation of the Chinese Academy of Sciences (to R.L.), Youth Innovation Promotion Association, Chinese Academy of Sciences (to R.L.), the Yunnan Applied Basic Research Key Projects (No. 2015FA027 to R.L.), and Diagnosis, Treatment and Transformation Engineering Technology Research Center for Renal Cell Carcinoma of Yunnan Province (to W.L.) .
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10998]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_肿瘤生物学
作者单位	1.Department of Urology of the First People’s Hospital of Yunnan Province, Kunming 650032, China 2.Medical College of Kunming University of Science and Technology, Kunming 650032, China 3.Yunnan University of Traditional Chinese Medicine, Kunming 650032, China 4.Key Laboratory of Animal Models and Human Disease Mechanisms of Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 5.College of Chemistry, Fuzhou University, Fuzhou 350116, China
推荐引用方式 GB/T 7714	Li W,Zhang HX,Chen CS,et al. Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells[J]. Acta Biochim Biophys Sin (Shanghai),2017,49(4):367–373.
APA	Li W.,Zhang HX.,Chen CS.,Liu R[].,Chen HJ[].,...&Chen X.(2017).Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells.Acta Biochim Biophys Sin (Shanghai),49(4),367–373.
MLA	Li W,et al."Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells".Acta Biochim Biophys Sin (Shanghai) 49.4(2017):367–373.