MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles

CORC > 化学研究所 > 中国科学院化学研究所 > 胶体、界面与化学热力学实验室

	MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles
	Qiao, Hongyu 1,2; Wang, Yabin 1; Zhang, Ruohan 3; Gao, Quansheng 6; Liang, Xiao 4; Gao, Lei 1; Jiang, Zhenhua 2; Qiao, Ruirui 5; Han, Dong 2; Zhang, Yan 1
刊名	BIOMATERIALS
	2017
卷号	112 页码:336-345
关键词	Dual-modality molecular imaging Atherosclerotic plaques Macrophages Nanoparticles
英文摘要	Rupture of vulnerable atherosclerotic plaque is the major pathological cause of luminal thrombosis in acute coronary syndromes. Since foamy macrophages have been identified as a prominent component in vulnerable atherosclerotic lesions and osteopontin (OPN) is reported to be highly expressed in foamy macrophages, OPN could be a potential target for vulnerable atherosclerotic plaque imaging. The current study designed an OPN-specific MRI/optical dual-modality probe to detect vulnerable plaques. Fluorescence imaging revealed that 24 h after injection of the Cy5.5-OPN-DMSA-MNPs (COD-MNPs), the atherosclerotic plaques in carotid artery exhibited significant higher signals in high fat diet (HFD) fed mice in comparison to the group injected with Cy5.5-IgG-DMSA-MNPs (CID-MNPs) or normal diet fed group injected with COD-MNPs (1.87 +/- 0.19 x 10(10) vs. 0.74 +/- 0.04 x 10(10), 0.73 +/- 0.03 x 10(10) p/sec/cm(2)/sr, P < 0.05). Meanwhile, MRI displayed stronger T-2 contrast enhancement 24 h post-injection at the area of atherosclerotic plaques in the carotid of HFD fed group injected with COD-MNPs than group injected with CID-MNPs or normal diet fed group injected with COD-MNPs (post/pre signal ratio: 0.64 +/- 0.04 vs. 0.95 +/- 0.02, 0.98 +/- 0.01, P < 0.05). As a dual-modality molecular probe, the resulting COD-MNPs conjugates exhibit promising potentials for noninvasive detection of vulnerable atherosclerotic plaque in vivo. (C) 2016 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/36433]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese PM Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China 2.Dept Cardiol, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Hepatobiliary & Pancretosplen Surg, Xian 710032, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China 6.Acad Mil Med Sci, Lab Anim Ctr, Beijing 100850, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Hongyu,Wang, Yabin,Zhang, Ruohan,et al. MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles[J]. BIOMATERIALS,2017,112:336-345.
APA	Qiao, Hongyu.,Wang, Yabin.,Zhang, Ruohan.,Gao, Quansheng.,Liang, Xiao.,...&Cao, Feng.(2017).MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles.BIOMATERIALS,112,336-345.
MLA	Qiao, Hongyu,et al."MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles".BIOMATERIALS 112(2017):336-345.