Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression

	Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression
	Qingli Liu; Meng Yang; Xuekun Fu; Renzhong Liu; Caijun Sun; Haobo Pan; Chi-Wai Wong; Min Guan
刊名	Molecular and Cellular Endocrinology
	2016
英文摘要	As a novel mediator of hepatic very low-density lipoproteins (VLDL) secretion, phospholipase A2 G12B (PLA2G12B) is transcriptionally regulated by hepatocyte nuclear factor-4 alpha (HNF-4α). Farnesoid X receptor (FXR) plays a critical role in maintaining bile acids and triglycerides (TG) homeostasis. Here we report that FXR regulates serum TG level in part through PLA2G12B. Activation of FXR by chenodeoxycholic acid (CDCA) or GW4064 significantly decreased PLA2G12B expression in HepG2 cells. PLA2G12B expression was transcriptionally repressed due to an FXR-mediated up-regulation of small heterodimer partner (SHP) which functionally suppresses HNF-4α activity. We found that hepatic PLA2G12B expression was suppressed and serum TG level reduced in high fat diet mice treated with CDCA. Concurrently, CDCA treatment lowered hepatic VLDL-TG secretion. Our data demonstrate that activation of FXR promotes TG lowering, not only by decreasing de novo lipogenesis but also reducing hepatic secretion of TG-rich VLDL particles in part through suppressing PLA2G12B expression.
收录类别	SCI
原文出处	http://www.ncbi.nlm.nih.gov/pubmed/27471003
语种	英语
WOS记录号	WOS:000403629800010
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10763]
专题	深圳先进技术研究院_医药所
作者单位	Molecular and Cellular Endocrinology
推荐引用方式 GB/T 7714	Qingli Liu,Meng Yang,Xuekun Fu,et al. Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression[J]. Molecular and Cellular Endocrinology,2016.
APA	Qingli Liu.,Meng Yang.,Xuekun Fu.,Renzhong Liu.,Caijun Sun.,...&Min Guan.(2016).Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression.Molecular and Cellular Endocrinology.
MLA	Qingli Liu,et al."Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression".Molecular and Cellular Endocrinology (2016).