NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling

	NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling
	Jianchao Zhang; Ximing Shao; Haiyan Sun; Ke Liu; Zhihao Ding; Juntao Chen; Lijing Fang; Wu Su; Yang Hong; Huashun Li
刊名	Oncotarget
	2016
英文摘要	Triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer with higher rates of early relapse and metastasis, is frequently associated with aberrant activation of epithelial-mesenchymal transition (EMT). Nonetheless, how EMT is initiated and regulated during TNBC progression is not well understood. Here, we report that NUMB is a negative regulator of EMT in both human mammary epithelial cells and breast cancer cells. Reduced NUMB expression was significantly associated with elevated EMT in TNBC. Conversely, overexpression of NUMB strongly attenuated the EMT program and metastasis of TNBC cell lines. Interestingly, we showed that NUMB employs different molecular mechanisms to regulate EMT. In normal mammary epithelial cells and breast cancer cells expressing wild-type p53, NUMB suppressed EMT by stabilizing p53. However, in TNBC cells, loss of NUMB facilitated the EMT program by activating Notch signaling. Consistent with these findings, low NUMB expression and high Notch activity were significantly correlated with the TNBC subtype in patients. Collectively, these findings reveal novel molecular mechanisms of NUMB in the regulation of breast tumor EMT, especially in TNBC.
收录类别	SCI
原文出处	https://www.researchgate.net/publication/305926623_NUMB_negatively_regulates_the_epithelial-mesenchymal_transition_of_triple-negative_breast_cancer_by_antagonizing_Notch_signaling
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10698]
专题	深圳先进技术研究院_医药所
作者单位	Oncotarget
推荐引用方式 GB/T 7714	Jianchao Zhang,Ximing Shao,Haiyan Sun,et al. NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling[J]. Oncotarget,2016.
APA	Jianchao Zhang.,Ximing Shao.,Haiyan Sun.,Ke Liu.,Zhihao Ding.,...&Hongchang Li.(2016).NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling.Oncotarget.
MLA	Jianchao Zhang,et al."NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling".Oncotarget (2016).