Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice.

	Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice.
	Li, Zhenzu; Zhang, Tingting; Lin, Zhuchun; Hou, Congzhe; Zhang, Jian; Men, Yuqin; Li, Huashun; Gao, Jiangang
刊名	PLOS ONE
	2016
英文摘要	Lethal giant larvae 1 (Lgl1) was initially identified as a tumor suppressor in Drosophila and functioned as a key regulator of epithelial polarity and asymmetric cell division. In this study, we generated Lgl1 conditional knockout mice mediated by Pax2-Cre, which is expressed in olfactory bulb (OB). Next, we examined the effects of Lgl1 loss in the OB. First, we determined the expression patterns of Lgl1 in the neurogenic regions of the embryonic dorsal region of the LGE (dLGE) and postnatal OB. Furthermore, the Lgl1 conditional mutants exhibited abnormal morphological characteristics of the OB. Our behavioral analysis exhibited greatly impaired olfaction in Lgl1 mutant mice. To elucidate the possible mechanisms of impaired olfaction in Lgl1 mutant mice, we investigated the development of the OB. Interestingly, reduced thickness of the MCL and decreased density of mitral cells (MCs) were observed in Lgl1 mutant mice. Additionally, we observed a dramatic loss in SP8(+) interneurons (e.g. calretinin and GABAergic/non-dopaminergic interneurons) in the GL of the OB. Our results demonstrate that Lgl1 is required for the development of the OB and the deletion of Lgl1 results in impaired olfaction in mice.
收录类别	SCI
原文出处	http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162126
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10694]
专题	深圳先进技术研究院_医药所
作者单位	PLOS ONE
推荐引用方式 GB/T 7714	Li, Zhenzu,Zhang, Tingting,Lin, Zhuchun,et al. Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice.[J]. PLOS ONE,2016.
APA	Li, Zhenzu.,Zhang, Tingting.,Lin, Zhuchun.,Hou, Congzhe.,Zhang, Jian.,...&Gao, Jiangang.(2016).Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice..PLOS ONE.
MLA	Li, Zhenzu,et al."Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice.".PLOS ONE (2016).