Transferrin Receptor Facilitates TGF-b and BMP Signaling Activation to Control Craniofacial Morphogenesis

	Transferrin Receptor Facilitates TGF-b and BMP Signaling Activation to Control Craniofacial Morphogenesis
	Run Lei; Ke Zhang; Ke Liu; Ximing Shao; Zhihao Ding; Fudi Wang; Yang Hong; Minyan Zhu; Hongchang Li; Huashun Li
刊名	Cell death and Disease
	2016
英文摘要	The Pierre Robin Sequence (PRS), consisting of cleft palate, glossoptosis and micrognathia, is a common human birth defect. However, how this abnormality occurs remains largely unknown. Here we report that neural crest cell (NCC)-specific knockout of transferrin receptor (Tfrc), a well known transferrin transporter protein, caused micrognathia, cleft palate, severe respiratory distress and inability to suckle in mice, which highly resemble human PRS. Histological and anatomical analysis revealed that the cleft palate is due to the failure of palatal shelves elevation that resulted from a retarded extension of Meckel’s cartilage. Interestingly, Tfrc deletion dramatically suppressed both transforming growth factor-β (ΤGF-β) and bone morphogenetic protein (BMP) signaling in cranial NCCs-derived mandibular tissues, suggesting that Tfrc may act as a facilitator of these two signaling pathways during craniofacial morphogenesis. Together, our study uncovers an unknown function of Tfrc in craniofacial development and provides novel insight into the etiology of PRS.
收录类别	SCI
原文出处	http://www.nature.com/cddis/journal/v7/n6/abs/cddis2016170a.html
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10688]
专题	深圳先进技术研究院_医药所
作者单位	Cell death and Disease
推荐引用方式 GB/T 7714	Run Lei,Ke Zhang,Ke Liu,et al. Transferrin Receptor Facilitates TGF-b and BMP Signaling Activation to Control Craniofacial Morphogenesis[J]. Cell death and Disease,2016.
APA	Run Lei.,Ke Zhang.,Ke Liu.,Ximing Shao.,Zhihao Ding.,...&Huashun Li.(2016).Transferrin Receptor Facilitates TGF-b and BMP Signaling Activation to Control Craniofacial Morphogenesis.Cell death and Disease.
MLA	Run Lei,et al."Transferrin Receptor Facilitates TGF-b and BMP Signaling Activation to Control Craniofacial Morphogenesis".Cell death and Disease (2016).