Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress

	Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress
	Gao, Ju; Li, Mengen; Qin, Siyue; Zhang, Ting; iang, Sicong; Hu, Yuan; Deng, Yongkang; Zhang, Chenliang; You, Dujuan; Li, Hongchang
刊名	AUTOPHAGY
	2016
英文摘要	During proteasomal stress, cells can alleviate the accumulation of polyubiquitinated proteins by targetingthem to perinuclear aggresomes for autophagic degradation, but the mechanism underlying the activation ofthis compensatory pathway remains unclear. Here we report that PINK1-s, a short form of Parkinson disease (PD)-related protein kinase PINK1 (PTEN induced putative kinase 1), is a major regulator ofaggresome formation. PINK1-s is extremely unstable due to its recognition by the N-end rule pathway, and tends to accumulate in the cytosol during proteasomal stress. Overexpression of PINK1-s inducesaggresome formation in cells with normal proteasomal activities, while loss of PINK1-s function leads to a significant decrease in the efficiency of aggresome formation induced by proteasomal inhibition. PINK1-s exerts its effect through phosphorylation of the ubiquitin-binding protein SQSTM1 (sequestosome 1) and increasing its ability to sequester polyubiquitinated proteins into aggresomes. These findings pinpointPINK1-s as a sensor of proteasomal activities that transduces the proteasomal impairment signal to theaggresome formation machinery.
收录类别	SCI
原文出处	http://www.tandfonline.com/doi/abs/10.1080/15548627.2016.1147667
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10682]
专题	深圳先进技术研究院_医药所
作者单位	AUTOPHAGY
推荐引用方式 GB/T 7714	Gao, Ju,Li, Mengen,Qin, Siyue,et al. Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress[J]. AUTOPHAGY,2016.
APA	Gao, Ju.,Li, Mengen.,Qin, Siyue.,Zhang, Ting.,iang, Sicong.,...&Jiang, Changan.(2016).Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.AUTOPHAGY.
MLA	Gao, Ju,et al."Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress".AUTOPHAGY (2016).