Remote and noninvasive NIR-triggered DOX release from DOX/ICG-loaded temperature-responsive nanoparticles to promote anti-tumor effect

	Remote and noninvasive NIR-triggered DOX release from DOX/ICG-loaded temperature-responsive nanoparticles to promote anti-tumor effect
	Zheng, Mingbin; Zhao, Pengfei; Luo, Zhenyu; Gong, Ping; Gao, Guanhui; Sheng, Zonghai; Zheng, Cuifang; Chen, Chi; Ma, Yifan; Cai, Lintao
刊名	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2016
英文摘要	Smart nanoparticles (NPs) that respond to external stimulations, including light, hyperthermia, reduction/oxidation and ultrasound have been developing to achieve optimal drug release in tumor tissues. However, applying these smart NPs to attain high antitumor performance is hampered by limited drug carriers and inefficient spatiotemporal control. In this study, we report a noninvasive NIR-driven, temperature-sensitive nanoparticles (DI-NPs) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). This theranostic delivery system applies thermoresponsive lipid to controllably release the drug, utilizes the fluorescence (FL) of DOX and ICG to real-time trace the distribution of NPs, and employs DOX/ICG to treat cancer by chemo/photothermal therapy. DI-NPs exhibit uniform size distribution, excellent FL/size stability, enhanced response to temperature, and increased drug release through laser irradiation. DI-NPs also show long retention time, spatiotemporally-controlled release of DOX in tumor tissues, and enhanced ICG and DOX accumulation. The thermo-sensitive DI-NPs manifest a superior efficiency to promote apoptosis of tumor cells, and completely suppress tumor growth without side-effect. This study may provide a new generation of smart strategy for combinatorial cancer therapy.
收录类别	SCI
原文出处	https://www.infona.pl/resource/bwmeta1.element.elsevier-51ce5ebc-984c-37d0-82bd-37977dd6ca75
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10668]
专题	深圳先进技术研究院_医药所
作者单位	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
推荐引用方式 GB/T 7714	Zheng, Mingbin,Zhao, Pengfei,Luo, Zhenyu,et al. Remote and noninvasive NIR-triggered DOX release from DOX/ICG-loaded temperature-responsive nanoparticles to promote anti-tumor effect[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2016.
APA	Zheng, Mingbin.,Zhao, Pengfei.,Luo, Zhenyu.,Gong, Ping.,Gao, Guanhui.,...&Cai, Lintao.(2016).Remote and noninvasive NIR-triggered DOX release from DOX/ICG-loaded temperature-responsive nanoparticles to promote anti-tumor effect.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.
MLA	Zheng, Mingbin,et al."Remote and noninvasive NIR-triggered DOX release from DOX/ICG-loaded temperature-responsive nanoparticles to promote anti-tumor effect".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016).