Composite magnetic nanocarriers for MRI and targeted drug delivery

	Composite magnetic nanocarriers for MRI and targeted drug delivery
	Ao, Lijiao; Huang, Liang; Su, Wu
刊名	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2016
英文摘要	The integration of individual superparamagnetic iron oxide nanoparticles Figure 1. Schematic illustration of the nanodrug construction and action process. (SPIONs) creates the synergistic magnetism, which is desired for enhanced magnetic response and T2 weighted MRI signal. We developed strategies for the assembly of SPIONs and their combination with chemotherapeutic agents, by employing novel nanocarriers. The heparin, a biodegradable and natural sourced polysaccharide, was derivitized with folic acid (FA) to achieve the amphiphilicity. After micellization of the polymer in water, the FA moieties served as both hydrophobic domains for cargos (SPIONs and doxorubicin) loading, and targeting ligands for cancer cells over-expressing FA receptors. These nanocarriers possessed a desirable size (70 nm), high colloidal stability and sustained doxorubicin release. The high magnetic content in each micelle realized their magnetic field guided targeting to cancer cells, combined with MRI diagnosis and chemotherapy. In another strategy, silica nanotubes (SNTs) were exploited as novel nanocarriers, for their elongated morphology (favourable for tumor penetration), hollow/porous structure and high chemical affinity to iron oxides. Based on these templates, we fabricated SNT@SPIONs composites by in-situ thermo-decomposition, skipping the conventional pre-synthesis and modification of both SPIONs and the templates. Owning to the synergistic magnetism of the densely loaded SPIONs, the composite nanotubes showed high T2 relaxation rate and quick magnetic response. After doxorubicin loading, the drug carriers were applied for magnetic guided tumor targeting, MRI diagnosis and chemotherapy to cancers.
收录类别	SCI
原文出处	https://www.infona.pl/resource/bwmeta1.element.elsevier-4f3e0a15-609c-3beb-929d-450d3373f23a
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10658]
专题	深圳先进技术研究院_医药所
作者单位	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
推荐引用方式 GB/T 7714	Ao, Lijiao,Huang, Liang,Su, Wu. Composite magnetic nanocarriers for MRI and targeted drug delivery[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2016.
APA	Ao, Lijiao,Huang, Liang,&Su, Wu.(2016).Composite magnetic nanocarriers for MRI and targeted drug delivery.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.
MLA	Ao, Lijiao,et al."Composite magnetic nanocarriers for MRI and targeted drug delivery".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016).