G alpha s regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression

	G alpha s regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression
	Liu Ke; Lin Quan; Wei Yanxia; He Renbing; Shao Ximing; Ding Zhihao; Zhang Jianchao; Zhu Minyan; Weinstein Lee S.; Hong Yang
刊名	NEUROSCIENCE LETTERS
	2015
英文摘要	Asymmetric cell division, which plays fundamental roles in generating cell diversity during development, requires elaborate interactions between extrinsic cues and intrinsic cues. However, the precise nature of this type of interaction and its involving signaling mechanisms are poorly understood. Here, we demonstrate that Gas is present in the proliferative region of ventricular zone in mouse developing neocortex and co-localizes with intrinsic cell fate determinant protein Numb in dividing apical progenitors. Targeted ablation of Gas subunit in the cortical progenitor causes an alteration from asymmetric to symmetric cell division, consequently leading to increased progenitor proliferation. Mechanistically, we show that Gas deletion significantly reduces Numb expression and activates notch signaling. Therefore, these results reveal a novel role of Gas in control of neural progenitor asymmetric cell division via suppressing Numb mediated Notch signaling inhibition. (C) 2015 Elsevier Ireland Ltd. All rights reserved
收录类别	SCI
原文出处	http://apps.webofknowledge.com/Search.do?product=UA&SID=V1miOCcGk5jmjeL74sA&search_mode=GeneralSearch&prID=52918d2d-37f0-4913-83e2-b60d0906caef
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7370]
专题	深圳先进技术研究院_医药所
作者单位	NEUROSCIENCE LETTERS
推荐引用方式 GB/T 7714	Liu Ke,Lin Quan,Wei Yanxia,et al. G alpha s regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression[J]. NEUROSCIENCE LETTERS,2015.
APA	Liu Ke.,Lin Quan.,Wei Yanxia.,He Renbing.,Shao Ximing.,...&Li Huashun.(2015).G alpha s regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression.NEUROSCIENCE LETTERS.
MLA	Liu Ke,et al."G alpha s regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression".NEUROSCIENCE LETTERS (2015).