Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo

	Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo
	Wan, Jiali; Wang, Jia-Hong; Liu, Ting; Xie, Zhixiong; Yu, Xue-Feng; Li, Wenhua
刊名	SCIENTIFIC REPORTS
	2015
英文摘要	Gold nanorods are a promising nanoscale material in clinical diagnosis and treatment. The physicochemical properties of GNRs, including size, shape and surface features, are crucial factors affecting their cytotoxicity. In this study, we investigated the effects of different aspect ratios and surface modifications on the cytotoxicity and cellular uptake of GNRs in cultured cells and in mice. The results indicated that the surface chemistry but not the aspect ratio of GNRs mediates their biological toxicity. CTAB-GNRs with various aspect ratios had similar abilities to induce cell apoptosis and autophagy by damaging mitochondria and activating intracellular reactive oxygen species (ROS). However, GNRs coated with CTAB/PSS, CTAB/PAH, CTAB/PSS/PAH or CTAB/PAH/PSS displayed low toxicity and did not induce cell death. CTAB/PAH-coated GNRs caused minimally abnormal cell morphology compared with CTAB/PSS and CTAB/PSS/PAH coated GNRs. Moreover, the intravenous injection of CTAB/PAH GNRs enabled the GNRs to reach tumor tissues through blood circulation in animals and remained stable, with a longer half-life compared to the other GNRs. Therefore, our results demonstrated that further coating can prevent cytotoxicity and cell death upon CTAB-coated GNR administration, similar to changing the GNR aspect ratio and CTAB/PAH coated GNRs show superior biological properties with better biocompatibility and minimal cytotoxicity.
收录类别	SCI
原文出处	http://www.ncbi.nlm.nih.gov/pubmed/26096816
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7350]
专题	深圳先进技术研究院_医药所
作者单位	SCIENTIFIC REPORTS
推荐引用方式 GB/T 7714	Wan, Jiali,Wang, Jia-Hong,Liu, Ting,et al. Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo[J]. SCIENTIFIC REPORTS,2015.
APA	Wan, Jiali,Wang, Jia-Hong,Liu, Ting,Xie, Zhixiong,Yu, Xue-Feng,&Li, Wenhua.(2015).Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo.SCIENTIFIC REPORTS.
MLA	Wan, Jiali,et al."Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo".SCIENTIFIC REPORTS (2015).