Smac Therapeutic Peptide Nanoparticles Inducing Apoptosis of Cancer Cells for Combination Chemotherapy with Doxorubicin

	Smac Therapeutic Peptide Nanoparticles Inducing Apoptosis of Cancer Cells for Combination Chemotherapy with Doxorubicin
	Mingxing Li; Peng Liu; Guanhui Gao; Jizhe Deng; Zhengyin Pan; Xu Wu; Gaofeng Xie; Caixia Yue; Chi Hin Cho; Yifan Ma
刊名	ACS Applied Materials & Interfaces
	2015
英文摘要	Smac-conjugated nanoparticle (Smac-NP) was designed to induce the apoptosis of cancer cells and as a drug carrier for combination therapy. It contained three parts, a SmacN7 peptide which could induce apoptosis of cancer cells by interacting with XIAPs, the cell penetrating domain rich in arginine, and four hydrophobic tails for self-assembled Smac-NP. We demonstrated that Smac-NPs exerted an antitumor effect in breast cancer cell MDA-MB-231 and nonsmall lung cancer (NSCLC) cell H460, which efficiently inhibited cancer cells proliferation without influencing normal liver cell lines LO2. Smac-NPs also significantly induced apoptosis of MDAMB-231 and H460 cells through activating pro-caspase-3, down-regulating the expression of antiapoptotic protein Bcl-2 and up-regulating the pro-apoptotic protein Bax. Furthermore, Smac-NPs could be explored as a drug delivery system to load hydrophobic drug such as DOX for combination therapy. The DOX-loaded nanoparticles (DOX-Smac-NPs) exhibited higher cellular uptake efficiency and antitumor effect. Our work provided a new insight into therapeutic peptides integrated with drug simultaneously in one system for cancer combination treatment.
收录类别	SCI
原文出处	http://pubs.acs.org/doi/pdf/10.1021/acsami.5b00329
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7341]
专题	深圳先进技术研究院_医药所
作者单位	ACS Applied Materials & Interfaces
推荐引用方式 GB/T 7714	Mingxing Li,Peng Liu,Guanhui Gao,et al. Smac Therapeutic Peptide Nanoparticles Inducing Apoptosis of Cancer Cells for Combination Chemotherapy with Doxorubicin[J]. ACS Applied Materials & Interfaces,2015.
APA	Mingxing Li.,Peng Liu.,Guanhui Gao.,Jizhe Deng.,Zhengyin Pan.,...&Lintao Cai.(2015).Smac Therapeutic Peptide Nanoparticles Inducing Apoptosis of Cancer Cells for Combination Chemotherapy with Doxorubicin.ACS Applied Materials & Interfaces.
MLA	Mingxing Li,et al."Smac Therapeutic Peptide Nanoparticles Inducing Apoptosis of Cancer Cells for Combination Chemotherapy with Doxorubicin".ACS Applied Materials & Interfaces (2015).