MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells

	MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells
	Ma, Zhongliang; Qiu, Xiang; Wang, Detao; Li, Yanli; Zhang, Bingjie; Yuan, Tianwei; Wei, Jiali; Zhao, Botao; Zhao, Xintai; Lou, Jiatao
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2015
英文摘要	MicroRNAs play important roles in carcinogenesis and tumor progress. Lung cancer is the leading cause of cancer mortality worldwide. In this study, the function of miR-181a-5p was investigated in non-small-cell lung cancer (NSCLC). Results showed that miR-181a-5pwas significantly decreased inNSCLC tissues and cell lines. The proliferation and migration of A549 cells transfected with miR-181a-5p mimic was significantly inhibited. Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p. Furthermore, Kras was downregulated bymiR-181a-5p at both transcriptional and translational levels. SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic inA549 cells. Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients.
收录类别	SCI
原文出处	http://abbs.oxfordjournals.org/content/47/8/630.short
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7329]
专题	深圳先进技术研究院_医药所
作者单位	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
推荐引用方式 GB/T 7714	Ma, Zhongliang,Qiu, Xiang,Wang, Detao,et al. MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2015.
APA	Ma, Zhongliang.,Qiu, Xiang.,Wang, Detao.,Li, Yanli.,Zhang, Bingjie.,...&Jin, Youxin.(2015).MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA.
MLA	Ma, Zhongliang,et al."MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015).