Multifunctional Layered Gadolinium Hydroxide Nanoplates for Ultrahigh Field Magnetic Resonance Imaging, Computed Tomography and Fluorescence Bioimaging

	Multifunctional Layered Gadolinium Hydroxide Nanoplates for Ultrahigh Field Magnetic Resonance Imaging, Computed Tomography and Fluorescence Bioimaging
	Wu, Min; Li, Lei; Yu, Xuefeng; Zhang, Daquan; Sun, Tianying; Li, Xue; Sun, Ling; Lui, Su; Huang, Xiaoqi; Bi, Feng
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2014
英文摘要	The commonly used clinical magnetic resonance imaging (MRI) contrast agents are generally suitable for MR systems with a magnetic field less than 3.0 T. However, these agents show low contrast efficacy for MR systems with ultrahigh fields >= 7.0 T, which is the direction that next-generation MRI scanners are heading. A new contrast agent consisting of layered gadolinium hydroxide nanoplates doped with Ce and Tb (LGdH:Ce, Tb NPs) is presented herein. This material exhibits excellent negative (T-2) contrast agent efficacy for 7.0 T MRI with a high r(2)/r(1) ratio of 48.80, whereas it exhibits a lower r(2)/r(1) ratio of 30.60 for 3.0 T MRI. Its performance as a T-2 contrast agent in ultrahigh field MRI of subcutaneous liver tumor-bearing nude mice is investigated, demonstrating its ability to be used as a negative target T-2 contrast agent to distinguish hepatic carcinoma from healthy tissues. Furthermore, the multifunctionality of the LGdH:Ce, Tb NPs as a contrast agent in X-ray computed tomography (CT) and fluorescence bioimaging is also presented, suggesting the possibility of integrating these imaging technologies for in-depth exploration of bioimaging.
收录类别	SCI
原文出处	http://chinesesites.library.ingentaconnect.com/content/asp/jbn/2014/00000010/00000012/art00011?token=0057189b03dee5ba6720297d76345f7b554a597a407b5e2c6b6d3f6a4b4b6e6e42576b6427387fa517dbec9
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/6145]
专题	深圳先进技术研究院_医药所
作者单位	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
推荐引用方式 GB/T 7714	Wu, Min,Li, Lei,Yu, Xuefeng,et al. Multifunctional Layered Gadolinium Hydroxide Nanoplates for Ultrahigh Field Magnetic Resonance Imaging, Computed Tomography and Fluorescence Bioimaging[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2014.
APA	Wu, Min.,Li, Lei.,Yu, Xuefeng.,Zhang, Daquan.,Sun, Tianying.,...&Zhu, Hongyan.(2014).Multifunctional Layered Gadolinium Hydroxide Nanoplates for Ultrahigh Field Magnetic Resonance Imaging, Computed Tomography and Fluorescence Bioimaging.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY.
MLA	Wu, Min,et al."Multifunctional Layered Gadolinium Hydroxide Nanoplates for Ultrahigh Field Magnetic Resonance Imaging, Computed Tomography and Fluorescence Bioimaging".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2014).