A folate-integrated magnetic polymer micelle for MRI and dual targeted drug delivery

	A folate-integrated magnetic polymer micelle for MRI and dual targeted drug delivery
	Ao, Lijiao; Wang, Bi; Liu, Peng; Huang, Liang; Yue, Caixia; Gao, Duyang; Wu, Chunlei; Su, Wu
刊名	Nanoscale
	2014
英文摘要	This paper devotes a novel micellar structure for cancer theranostics by incorporating magnetic and therapeutic functionalities into a natural sourced targetingpolymer vehicle. Heparin-folic acid micelles taking advantage of both excellent loading capability and cancer targeting ability have been employed to simultaneously incorporate superparamagnetic iron oxide nanoparticles (SPIONs) and doxorubicin through an ultrasonication-assisted microemulsion method. In this system, folic acids not only take the responsibility of micelle construction, but also facilitate cellular uptake due to their specific reorganization by MCF-7 cells over-expressing folate receptors. The obtained micelles exhibit good colloidal stability, a high magnetic content, considerable drug loading and sustained in vitro drug release. These clustered SPIONs exhibited high r(2) relaxivity (243.65 mM(-1) s(-1)) and further served as efficient probes for MR imaging. Notably, the transport efficiency of these micelles could be significantly improved under an external magnetic field, owing to their quick magneticresponse. As a result, the as-proposed micelle shows great potential in multimodal theranostics, including active targeting, MRI diagnosis and drug delivery.
收录类别	SCI
原文出处	http://pubs.rsc.org/en/Content/ArticleLanding/2014/NR/C4NR02484B#!divAbstract
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/6124]
专题	深圳先进技术研究院_医药所
作者单位	Nanoscale
推荐引用方式 GB/T 7714	Ao, Lijiao,Wang, Bi,Liu, Peng,et al. A folate-integrated magnetic polymer micelle for MRI and dual targeted drug delivery[J]. Nanoscale,2014.
APA	Ao, Lijiao.,Wang, Bi.,Liu, Peng.,Huang, Liang.,Yue, Caixia.,...&Su, Wu.(2014).A folate-integrated magnetic polymer micelle for MRI and dual targeted drug delivery.Nanoscale.
MLA	Ao, Lijiao,et al."A folate-integrated magnetic polymer micelle for MRI and dual targeted drug delivery".Nanoscale (2014).