Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance

	Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance
	Zhu, Huijun; Chen, Hongbo; Zeng, Xiaowei; Wang, Zhongyuan; Zhang, Xudong; Wu, Yanping; Gao, Yongfeng; Zhang, Jinxie; Liu, Kewei; Liu, Ranyi
刊名	BIOMATERIALS
	2014
英文摘要	We report a strategy to make use of poly(lactic-co-glycolic acid) nanoparticle (PLGA NPs) for co-delivery of docetaxel (DTX) as a model anticancer drugtogether with vitamin E TPGS. The latter plays a dual role as a pore-forming agent in the nanopartides that may result in smaller particle size, higher drugencapsulation efficiency and faster drug release, and also as a bioactive agent that could inhibit P-glycoprotein to overcome multi-drug resistance of the cancer cells, The DTX-loaded PLGA NPs of 0, 10, 20 and 40% TPGS were prepared by the nanoprecipitation method and then characterized for their size and size distribution, surface morphology, physical status and encapsulation efficiency of the drug in the NPs. All four NPs were found of size ranged 100-120 nm and EE ranged 85-95% at drug loading level around 10%. The in vitro evaluation showed that the 48 h IC50 values of the free DTX and the DTX-loaded PLGA NPs of0, 10,20% TPGS were 2.619 and 0.474, 0.040, 0.009 mu g/mL respectively, which means that the PLGA NPs formulation could be 5.57 fold effective than the free DTX and that the DTX-loaded PLGA NPs of 10 or 20% TPGS further be 11.85 and 52.7 fold effective than the DTX-loaded PLGA NPs of no TPGS(therefore, 66.0 and 284 fold effective than the free DTX). Xenograft tumor model and immunohistological staining analysis further confirmed the advantages ofthe strategy of co-delivery of anticancer drugs with TPGS by PLGA NPs. (c) 2013 Elsevier Ltd. All rights reserved.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S014296121301452X
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/6118]
专题	深圳先进技术研究院_医药所
作者单位	BIOMATERIALS
推荐引用方式 GB/T 7714	Zhu, Huijun,Chen, Hongbo,Zeng, Xiaowei,et al. Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance[J]. BIOMATERIALS,2014.
APA	Zhu, Huijun.,Chen, Hongbo.,Zeng, Xiaowei.,Wang, Zhongyuan.,Zhang, Xudong.,...&Feng, Si-Shen.(2014).Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance.BIOMATERIALS.
MLA	Zhu, Huijun,et al."Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance".BIOMATERIALS (2014).