An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism

	An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism
	Cui, Xu; Zhang, Yadong; Wang, Hui; Gu, Yifei; Li, Le; Zhou, Jie; Zhao, Shichang; Huang, Wenha; Zhou, Nai; Wang, Deping
刊名	Journal of Non-Crystalline Solids
	2014
英文摘要	There is a need for synthetic biomaterials to reconstruct bone defects using minimal invasive surgery. In this study, the preparation, bioactivity and settingmechanism of an injectable cement composed of borate bioactive glass particles and a chitosan solution was evaluated as a function of varying solid to liquid (SL) ratio. As the SL ratio increased from 1.0. g/ml to 2.5. g/ml, the injectability and initial setting time decreased from 97. ±. 1% to 84. ±. 10% and from 16.9. ±. 0.9. min to 3.0. ±. 0.5. min, respectively, while the compressive strength of the cement increased from 8. ±. 2. MPa to 31. ±. 2. MPa. The cement maintained its cohesiveness in a vigorously stirred aqueous medium. When immersed in phosphate-buffered saline, the glass phase reacted and converted to hydroxyapatite. The setting mechanism of the cement appeared to involve a combination of processes, such as the sol-gel transition of the chitosan solution, formation of an interlocked interface between the converted glass surface and the chitosan, and bonding between the converted glass surface and the functional groups of the chitosan. By controlling the reaction between the glass particles and the chitosan solution, injectable cements can be created with the requisite workability, degradation, strength and bioactivity for bonerepair applications. © 2015.
收录类别	EI
原文出处	http://www.sciencedirect.com/science/article/pii/S0022309315300612
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/6098]
专题	深圳先进技术研究院_医药所
作者单位	Journal of Non-Crystalline Solids
推荐引用方式 GB/T 7714	Cui, Xu,Zhang, Yadong,Wang, Hui,et al. An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism[J]. Journal of Non-Crystalline Solids,2014.
APA	Cui, Xu.,Zhang, Yadong.,Wang, Hui.,Gu, Yifei.,Li, Le.,...&Rahaman, Mohamed N..(2014).An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism.Journal of Non-Crystalline Solids.
MLA	Cui, Xu,et al."An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism".Journal of Non-Crystalline Solids (2014).