Cationic polypeptide micelle-based antigen delivery system: a simple and robust adjuvant to improve vaccine efficacy

	Cationic polypeptide micelle-based antigen delivery system: a simple and robust adjuvant to improve vaccine efficacy
	Luo, Zichao; Li, Ping; Deng, Jizhe; Gao, Ningning; Zhang, Yijuan; Pan, Hong; Liu, Lanlan; Wang, Ce; Cai, Lintao; Ma, Yifan
刊名	JOURNAL OF CONTROLLED RELEASE
	2013
英文摘要	Modern subunit vaccines with purified or recombinant antigens are important alternatives to the traditional vaccines. However, there remains a big challenge toelicit potent antibody production and CD8 T cell response. Nanoparticle-based antigen delivery systems have emerged as an innovative strategy to improve theefficacy of subunit vaccines. The present study reported self-assembled cationic micelles based on poly(ethylene glycol)-b-poly(L-lysine)-b-poly(L-leucine) (PEG-PLL-PLLeu) hybrid polypeptides as a simple and potent vaccine delivery system. The results showed that the PEG-PLL-PLLeumicelles spontaneously encapsulated OVA antigens with great loading capacity (LC = 55%) and stability. More importantly, the polypeptide micelle formulations robustly enhancedvaccine-induced antibody production by 70-90 fold, which could be due to their capability of inducing dendritic cell maturation, enhancing antigen uptake and presentation, as well as promoting germinal center formation. Furthermore, the polypeptide micelles could simultaneously encapsulate OVA and polyriboinosinic: polyribocytidylic acid (PIC), a TLR3 agonist, to synergistically augment tumor specific cytotoxic-T-lymphocyte (CTL) response. Hence, thepolypeptide micelle-based antigen delivery system could be a robust adjuvant to enhance vaccine-induced immune responses. (C) 2013 Elsevier B. V. All rights reserved.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S0168365913003179
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5188]
专题	深圳先进技术研究院_医药所
作者单位	JOURNAL OF CONTROLLED RELEASE
推荐引用方式 GB/T 7714	Luo, Zichao,Li, Ping,Deng, Jizhe,et al. Cationic polypeptide micelle-based antigen delivery system: a simple and robust adjuvant to improve vaccine efficacy[J]. JOURNAL OF CONTROLLED RELEASE,2013.
APA	Luo, Zichao.,Li, Ping.,Deng, Jizhe.,Gao, Ningning.,Zhang, Yijuan.,...&Ma, Yifan.(2013).Cationic polypeptide micelle-based antigen delivery system: a simple and robust adjuvant to improve vaccine efficacy.JOURNAL OF CONTROLLED RELEASE.
MLA	Luo, Zichao,et al."Cationic polypeptide micelle-based antigen delivery system: a simple and robust adjuvant to improve vaccine efficacy".JOURNAL OF CONTROLLED RELEASE (2013).