Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges

	Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges
	Xiao Jia; Guo Rui; Fung Man Lung; Liong Emily C.; Tipoe George L.
刊名	HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
	2013
英文摘要	BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver injury and mortality in Western countries and China. However, asto date, there is no direct and effective therapy for this disease. The aim of this review is to analyze the key progress and challenges of main currenttherapeutic approaches in NAFLD. DATA SOURCE: We carried out a PubMed search of English-language articles relevant to NAFLD therapy. RESULTS: There are two major therapeutic strategies for NAFLD treatment: (1) lifestyle interventions (including weight reduction, dietary modification and physical exercise) and (2) pharmaceutical therapies. Lifestyle interventions, particularly chronic and moderate intensity exercise, are the most effective and recognized clinical therapies for NAFLD. For pharmaceutical therapies, although their effects and mechanisms have been extensively investigated in laboratory studies, they still need further tests and investigations in clinical human trials. CONCLUSION: Future advancement of NAFLD therapy should focus on the mechanistic studies on cell based and animal models and human clinical trials of exercise, as well as the combination of lifestyle intervention and pharmaceutical therapy specifically targeting main signaling pathways related to lipid metabolism, oxidative stress and inflammation.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S1499387213600211
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5185]
专题	深圳先进技术研究院_医药所
作者单位	HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
推荐引用方式 GB/T 7714	Xiao Jia,Guo Rui,Fung Man Lung,et al. Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges[J]. HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL,2013.
APA	Xiao Jia,Guo Rui,Fung Man Lung,Liong Emily C.,&Tipoe George L..(2013).Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges.HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL.
MLA	Xiao Jia,et al."Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges".HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2013).