Lipid–Polymer Nanoparticles Encapsulating Doxorubicin and 2′-Deoxy-5-azacytidine Enhance the Sensitivity of Cancer Cells to Chemical Therapeutics

	Lipid–Polymer Nanoparticles Encapsulating Doxorubicin and 2′-Deoxy-5-azacytidine Enhance the Sensitivity of Cancer Cells to Chemical Therapeutics
	Su, Xianwei; Wang, Zhaohui; Li, Lili; Zheng, Mingbin; Zheng, Cuifang; Gong, Ping; Zhao, Pengfei; Ma, Yifan; Tao, Qian; Cai, Lintao
刊名	MOLECULAR PHARMACEUTICS
	2013
英文摘要	Nanomedcine holds great potential in cancer therapy due to its flexibility on drug delivery, protection, releasing, and targeting. Epigenetic drugs, such as 2'-deoxy-5-azacytidine (DAC), are able to cause reactive expression of tumor suppressor genes (TSG) in human cancers and, therefore, might be able toenhance the sensitivity of cancer cells to chemotherapy. In this report, we fabricated a lipid-polymer nanoparticle for codelivery of epigenetic drug DAC and traditional chemotherapeutic drug (DOX) to cancer cells and monitored the growth inhibition of the hybrid nanoparticles (NPs) on cancer cells. Our results showed that NPs encapsulating DAC, DOX, or both, could be effectively internalized by cancer cells. More importantly, incorporating DAC into NPs significantly enhanced the sensitivity of cancer cells to DOX by inhibiting cell growth rate and inducing cell apoptosis. Further evidence indicated that DAC encapsulated by NPs was able to rescue the expression of silenced TSG in cancer cells. Overall our work clearly suggested that the resulting lipid-polymernanoparticle is a potential tool for combining epigenetic therapy and chemotherapy.
收录类别	SCI
原文出处	http://pubs.acs.org/doi/abs/10.1021/mp300675c
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5162]
专题	深圳先进技术研究院_医药所
作者单位	MOLECULAR PHARMACEUTICS
推荐引用方式 GB/T 7714	Su, Xianwei,Wang, Zhaohui,Li, Lili,et al. Lipid–Polymer Nanoparticles Encapsulating Doxorubicin and 2′-Deoxy-5-azacytidine Enhance the Sensitivity of Cancer Cells to Chemical Therapeutics[J]. MOLECULAR PHARMACEUTICS,2013.
APA	Su, Xianwei.,Wang, Zhaohui.,Li, Lili.,Zheng, Mingbin.,Zheng, Cuifang.,...&Cai, Lintao.(2013).Lipid–Polymer Nanoparticles Encapsulating Doxorubicin and 2′-Deoxy-5-azacytidine Enhance the Sensitivity of Cancer Cells to Chemical Therapeutics.MOLECULAR PHARMACEUTICS.
MLA	Su, Xianwei,et al."Lipid–Polymer Nanoparticles Encapsulating Doxorubicin and 2′-Deoxy-5-azacytidine Enhance the Sensitivity of Cancer Cells to Chemical Therapeutics".MOLECULAR PHARMACEUTICS (2013).