Bone regeneration: importance of local pH—strontium-doped borosilicate scaffold

	Bone regeneration: importance of local pH—strontium-doped borosilicate scaffold
	Shen, Yuhui; Liu, Waiching; Wen, Chunyi; Pan, Haobo; Wang, Ting; Darvell, Brian W.; Lu, William W.; Huang, Wenhai
刊名	JOURNAL OF MATERIALS CHEMISTRY
	2012
英文摘要	The effect of local pH on bone regeneration has never been properly studied or discussed. However, using a microelectrode, the pH on the surface of implant materials, rather than in the bulk, is measurable so that the biological response based on the local environment can be studied. It was found that the osteoblast viability was significantly enhanced with an increase of pH, to an optimum level at similar to pH 8-8.5; in contrast, the activity fell markedly below pH 6. The effect of strontium on osteoblast proliferation was further increased at pH similar to 8, suggesting a possible new approach for enhancing its activity in the treatment of osteoporosis. No stimulation of osteoblast proliferation was found for boron at normal physiological pH but, surprisingly, such an effect was found at pH 8.5. For the degradation of strontium-doped borosilicate, the ambient alkaline pH not only enhanced the activity of strontium and boron, but also facilitated the nucleation of apatite, as indicated by the newly formed bony tissue. Consequently, appropriately designed biomaterials, which create such an ideal ambient alkaline environment for bone regeneration, may be crucial aspects for bone substitutes.
收录类别	SCI
原文出处	http://pubs.rsc.org/en/Content/ArticleLanding/2012/JM/c2jm16141a#!divAbstract
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4293]
专题	深圳先进技术研究院_医药所
作者单位	JOURNAL OF MATERIALS CHEMISTRY
推荐引用方式 GB/T 7714	Shen, Yuhui,Liu, Waiching,Wen, Chunyi,et al. Bone regeneration: importance of local pH—strontium-doped borosilicate scaffold[J]. JOURNAL OF MATERIALS CHEMISTRY,2012.
APA	Shen, Yuhui.,Liu, Waiching.,Wen, Chunyi.,Pan, Haobo.,Wang, Ting.,...&Huang, Wenhai.(2012).Bone regeneration: importance of local pH—strontium-doped borosilicate scaffold.JOURNAL OF MATERIALS CHEMISTRY.
MLA	Shen, Yuhui,et al."Bone regeneration: importance of local pH—strontium-doped borosilicate scaffold".JOURNAL OF MATERIALS CHEMISTRY (2012).