Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging

	Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging
	Zheng, Cuifang; Zheng, Mingbin; Gong, Ping; Jia, Dongxue; Zhang, Pengfei; Shi, Bihua; Sheng, Zonghai; Ma, Yifan; Cai, Lintao
刊名	BIOMACROMOLECULES
	2012
英文摘要	Indocyanine green (ICG) is a near-infrared (NIR) fluorescence dye for extensive biological application, but limited by its poor aqueous stability in vitro, concentration-dependent aggregation, rapid elimination from the body, and lack of target specificity. In this paper, to overcome these limitations, folate receptor-targeted, ICG dye-doped poly(D,L-lactide-co-glycolid) (PLGA) lipid nanoparticles (FA-ICG-PLGA-lipid NPs) were constructed by a single-step self-assemble and nanoprecipitation method. The prepared FA-ICG-PLGA-lipid NPs exhibited good biocompatibility, monodispersity, excellent NIR penetration ability, significant stability against photobleaching and long circulation time. The intracellular uptake experiment proved the targeting efficacy of the FA-ICG-PLGA-lipid NPs was more effective in folate receptor over-expressing MCF-7 cells than folate receptor negative A549 cells. Furthermore, the in vivoexperiments showed the FA-ICG-PLGA-lipid NPs were specifically targeted to the tumor, and its circulation time was much longer than free ICG. These biocompatible and biodegradable NIR-NPs prove a potential application in tumor diagnosis and targeted imaging due to its high aqueous stability, excellent NIR optical properties and significantly targeting property in vivo. (C) 2012 Elsevier Ltd. All rights reserved.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S0142961212004668
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4287]
专题	深圳先进技术研究院_医药所
作者单位	BIOMACROMOLECULES
推荐引用方式 GB/T 7714	Zheng, Cuifang,Zheng, Mingbin,Gong, Ping,et al. Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging[J]. BIOMACROMOLECULES,2012.
APA	Zheng, Cuifang.,Zheng, Mingbin.,Gong, Ping.,Jia, Dongxue.,Zhang, Pengfei.,...&Cai, Lintao.(2012).Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging.BIOMACROMOLECULES.
MLA	Zheng, Cuifang,et al."Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging".BIOMACROMOLECULES (2012).