Template-free synthesis of hollow/porous organosilica-Fe3O4 hybrid nanocapsules towards MRI-guided high intensity focused ultrasound therapy.

	Template-free synthesis of hollow/porous organosilica-Fe3O4 hybrid nanocapsules towards MRI-guided high intensity focused ultrasound therapy.
	Ma, Ming; Yan, Fei; Yao, Minghua; Wei, Zijun; Zhou, Dongliang; Yao, Heliang; Zheng, Heirong; Chen, Hangrong; Shi, Jianlin
刊名	ACS Applied Materials & Interfaces
	2016
英文摘要	Entirely differing from the common templating-based multistep strategy for fabricating multifunctional hollow mesoporous silica nanoparticles (HMSN), a facile and template-free synthetic strategy has been established to construct a unique hollow/mesoporous organosilica nanocapsule (OSNC) concurrently encapsulating both isopentyl acetate (PeA) liquid and superparamagnetic iron oxides inside (denoted as PeA@OSNC). This novel material exhibits ultrasmall and uniform particle size (∼82 nm), high surface area (∼534 m2·g-1), and excellent colloidal stability in aqueous solution. The oil-phase PeA with relatively low boiling point (142 °C) and high volatility not only plays a crucial role in formation of a large hollow cavity from the viewpoint of structural design but also enables the PeA@OSNC to act as an efficient enhancement agent in high-intensity focused ultrasound (HIFU) therapy. Moreover, the unique satellite-like distribution of Fe3O4 nanoparticles (NP) on the organosilica shell offered excellent magnetic resonance imaging (MRI) contrast capability of PeA@OSNC in vitro and in vivo. More importantly, such a novel theranostic agent has favorable biosafety, which is very promising for future clinical application in MRI-guided HIFU therapy
收录类别	SCI
原文出处	http://pubs.acs.org/doi/abs/10.1021/acsami.6b10370
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10489]
专题	深圳先进技术研究院_医工所
作者单位	ACS Applied Materials & Interfaces
推荐引用方式 GB/T 7714	Ma, Ming,Yan, Fei,Yao, Minghua,et al. Template-free synthesis of hollow/porous organosilica-Fe3O4 hybrid nanocapsules towards MRI-guided high intensity focused ultrasound therapy.[J]. ACS Applied Materials & Interfaces,2016.
APA	Ma, Ming.,Yan, Fei.,Yao, Minghua.,Wei, Zijun.,Zhou, Dongliang.,...&Shi, Jianlin.(2016).Template-free synthesis of hollow/porous organosilica-Fe3O4 hybrid nanocapsules towards MRI-guided high intensity focused ultrasound therapy..ACS Applied Materials & Interfaces.
MLA	Ma, Ming,et al."Template-free synthesis of hollow/porous organosilica-Fe3O4 hybrid nanocapsules towards MRI-guided high intensity focused ultrasound therapy.".ACS Applied Materials & Interfaces (2016).