A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging | |
Yang, Yongfeng; Bec, Julien; Zhou, Jian; Zhang, Mengxi; Judenhofer, Martin S.; Cherry, Simon R. | |
刊名 | JOURNAL OF NUCLEAR MEDICINE |
2016 | |
英文摘要 | We developed a prototype small-animal PET scanner based on depth-encoding detectors using dual-ended readout of small scintillator elements to produce high and uniform spatial resolution suitable for imaging themouse brain. Methods: The scanner consists of 16 tapered dual-ended-readout detectors arranged in a 61-mm-diameter ring. The axial field of view (FOV) is 7 mm, and the transaxial FOV is 30 mm. The scintillator arrays consist of 14 x 14 lutetium oxyorthosilicate elements, with a crystal size of 0.43 x 0.43 mm at the front end and 0.80 x 0.43 mm at the back end, and the crystal elements are 13 mm long. The arrays are read out by 8 x 8 mm and 13 x 8 mm position-sensitive avalanche photodiodes (PSAPDs) placed at opposite ends of the array. Standard nuclear-instrumentation-module electronics and a custom-designed multiplexer are used for signal processing. Results: The detector performance was measured, and all but the crystals at the very edge could be clearly resolved. The average intrinsic spatial resolution in the axial direction was 0.61 mm. A depth-of-interaction resolution of 1.7 mm was achieved. The sensitivity of thescanner at the center of the FOV was 1.02% for a lower energy threshold of 150 keV and 0.68% for a lower energy threshold of 250 keV. The spatial resolution within a FOV that can accommodate the entire mousebrain was approximately 0.6 mm using a 3-dimensional maximum-likelihood expectation maximization reconstruction. Images of a hot-rod micro phantom showed that rods with a diameter of as low as 0.5 mm could be resolved. The first in vivo studies were performed using F-18-fluoride and confirmed that a 0.6-mmresolution can be achieved in the mouse head in vivo. Brain imaging studies with F-18-FDG were also performed. Conclusion: We developed a prototype PET scanner that can achieve a spatial resolutionapproaching the physical limits of a small-bore PET scanner set by positron range and detector interaction. We plan to add more detector rings to extend the axial FOV of the scanner and increase sensitivity. |
收录类别 | SCI |
原文出处 | http://jnm.snmjournals.org/content/57/7/1130.short |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.siat.ac.cn:8080/handle/172644/10465] |
专题 | 深圳先进技术研究院_医工所 |
作者单位 | JOURNAL OF NUCLEAR MEDICINE |
推荐引用方式 GB/T 7714 | Yang, Yongfeng,Bec, Julien,Zhou, Jian,et al. A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging[J]. JOURNAL OF NUCLEAR MEDICINE,2016. |
APA | Yang, Yongfeng,Bec, Julien,Zhou, Jian,Zhang, Mengxi,Judenhofer, Martin S.,&Cherry, Simon R..(2016).A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging.JOURNAL OF NUCLEAR MEDICINE. |
MLA | Yang, Yongfeng,et al."A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging".JOURNAL OF NUCLEAR MEDICINE (2016). |
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